Figure 2.

Molecular clearance from CSF and brain parenchyma and association with ventricular reflux. Comparison of time course of CSF tracer level within (A) CSF of cisterna magna and (B) parenchyma of ERC in iNPH (n = 34) and REF (n = 17) subjects. The CSF tracer level is expressed as mean (standard error) percentage change of normalized signal unit ratio (*P = 0.013, ** P < 0.001; independent samples t-test). Comparisons of (C) one-night clearance (n = 50) and (D) two-night clearance (n = 27) of CSF tracer from cisterna magna in individuals with ventricular reflux grades 0–2 (n = 18) and 3–4 (n = 33). Both one- and two-night clearances were impaired in the individuals with ventricular reflux grades 3–4. Comparisons of (E) one-night clearance (n = 50) and (F) two-night clearance (n = 27) of CSF tracer from parenchyma of ERC in individuals with ventricular reflux grades 0–2 (n = 18) and 3–4 (n = 33) showed significantly impaired one-night clearance in individuals with ventricular reflux grades 3–4. Statistical differences are indicated, and were determined by independent samples t-test. Error bars 95% CI