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. 2020 Dec 8;11:524413. doi: 10.3389/fgene.2020.524413

FIGURE 2.

FIGURE 2

The ratio of unique to total sequences (U/T) of 6 IGHJ genes in the in-frame and out-of-frame BCR-H repertoires from different subjects. (A) The IGHJ U/T ratio of BCR-H repertoires from 6 Healthy volunteers. (B) The IGHJ U/T ratio of BCR-H repertoires from public data. (C) The IGHJ U/T ratio of IgM-H repertoires from volunteers before and after immunization with the HBV vaccine. (D) The IGHJ U/T ratio of IgG-H repertoires from volunteers before and after immunization with the HBV vaccine. (E) The IGHJ U/T ratio of BCR-H repertoires from SLE volunteers. (F) The IGHJ U/T ratio of BCR-H repertoires from breast cancer volunteers. (G) The IGHJ U/T ratio of BCR-H repertoires from volunteers with a high titer of HbsAb. We used bar chart for sample groups with n = 2 (B) and IMGT (C), while used box plot for sample groups with n ≥ 3 using a one-way ANOVA with Bonferroni correction (A,D–G). All statistically significant differences are indicated as *p < 0.05; **p < 0.01, and ***p < 0.001.