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. 2020 Dec 8;11:598939. doi: 10.3389/fphar.2020.598939

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Copyright © 2020 Long, Lin, Zhang, Zhang, Xiao and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AT-I inhibited NMU-induced rat breast cancer. The NMU-induced rats were treated with control or AT-I for 9 weeks. (A) Body weights of rats in all groups at 0, 3, 5 and 9 weeks. (B) Palpable tumor incidence was recorded every week. (C) Average tumor number at 9 week. (D) Average tumor volume at 9 week. (E, F) Rat breast tissues were kept to detect TLR4/NF-κB pathway by western blot assay at the end of experiment. (G, H, I) TNF-α, IL-6 and IL-1β levels in rat breast tissues were analyzed by ELISA at the end of experiment. Significant differences between different groups were indicated as *p < 0.05, **p < 0.01, ***p < 0.001, vs. the NMU group, n = 6.