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. 2020 Dec 8;11:585203. doi: 10.3389/fgene.2020.585203

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Copyright © 2020 Rao, Mao, Xia, Zhang, Hu, Yuan, Yang, Yan, Deng, Cai, Mao, Li and Liao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of BiP (GRP78), PERK, eIF2α/p-eIF2α, and ATF4 was increased in B. pseudomallei-infected A549 cells. (A) Western blot analysis of DEGs involved in UPR challenged with B. pseudomallei. GAPDH and β-actin were used as loading controls, and all experiments were performed three times. (B) The relative expression level of DEGs in every group. Cells without infection (0 hpi) was the control group. A t-test was performed to compare the means, and the asterisks represent the P-value as follows * <0.05, n.s = non-significant, and P-value > 0.05 is considered not statistically significant.