Table 1.
Differentially expressed genes of A549 infected with Burkholderia pseudomallei at 6 and 12 hpi in contrast to control cells (0 hpi).
| Gene | Functional category and protein name | mRNA accession | Fold change (vs. 0 hpi) | |
|---|---|---|---|---|
| 6 hpi | 12 hpi | |||
| Unfolded protein response | ||||
| EIF2S1 | Eukaryotic translation initiation factor 2, subunit 1 alpha | NM_004094 | 1.72 | 1.71 |
| HSPA5 | Endoplasmic reticulum chaperone BiP | NM_005347 | 1.65 | 1.54 |
| ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | NM_001675 | 1.59 | 1.71 |
| Inflammatory response | ||||
| SPINK5 | Serine protease inhibitor Kazal-type 5 | NM_001127698 | 0.36 | 0.52 |
| MAP2K6 | Mitogen-activated protein kinase kinase 6 | NM_002758 | 0.36 | 0.65 |
| IL20RB | Interleukin-20 receptor subunit beta | NM_144717 | 0.54 | 0.61 |
| THBS1 | Thrombospondin-1 | NM_003246 | 2.15 | 1.96 |
| TNFAIP3 | Tumor necrosis factor alpha-induced protein 3 | NM_006290 | 2.70 | 2.32 |
| IL6 | Interleukin-6 | NM_000600 | 2.72 | 2.12 |
| IL1A | Interleukin-1 alpha | NM_000575 | 0.58 | 0.54 |
| ALOX5AP | Arachidonate 5-lipoxygenase-activating protein | NM_001629 | 0.48 | 0.54 |
| GKN2 | Gastrokine-2 | NM_182536 | 2.15 | 2.20 |
| F3 | Tissue factor | NM_001993 | 2.28 | 2.11 |
| NFκB2 | Nuclear factor NF-kappa-B p100 subunit | NM_001077494 | 1.58 | 1.64 |
| Cell migration | ||||
| ANXA9 | Annexin A9 | NM_003568 | 0.57 | 0.42 |
| CLDN7 | Claudin-7 | NM_001307 | 0.64 | 0.47 |
| ICAM1 | Intercellular adhesion molecule 1 | NM_000201 | 1.86 | 1.50 |
| UBASH3B | Ubiquitin-associated and SH3 domain-containing protein B | NM_032873 | 2.40 | 2.15 |
| SAMD9L | Sterile alpha motif domain-containing protein 9-like | NM_152703 | 0.56 | 0.63 |
| CTGF | Connective tissue growth factor | NM_001901 | 1.69 | 1.72 |
| Apoptotic process | ||||
| GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | NM_001924 | 2.03 | 1.69 |
| FOSL1 | Fos-related antigen | NM_005438 | 2.20 | 1.99 |
| MT1X | Metallothionein-1X | NM_005952 | 2.20 | 1.88 |
| BCL2L15 | BCL2-like 15 | NM_001010922 | 0.63 | 0.63 |
| IGFBP3 | Insulin-like growth factor-binding protein 3 | NM_001013398 | 1.83 | 1.63 |
| Regulation of transport | ||||
| RAB26 | Ras-related protein Rab-26 | NM_014353 | 0.55 | 0.57 |
| ANKRD1 | Ankyrin repeat domain-containing protein 1 | NM_014391 | 2.51 | 2.18 |
| STC2 | Stanniocalcin-2 | NM_003714 | 2.82 | 2.44 |
| DENND2C | DENN domain-containing protein 2C | NM_198459 | 1.89 | 1.78 |
| PLD1 | Phospholipase D1 | NM_002662 | 0.60 | 0.67 |
| G protein-coupled receptor signaling pathway | ||||
| PPYR1 | Neuropeptide Y receptor type 4 | NM_005972 | 0.42 | 0.62 |
| GPRIN3 | G protein-regulated inducer of neurite outgrowth 3 | NM_198281 | 0.43 | 0.58 |
| Cytoskeletal protein binding | ||||
| EPB41L4A | Band 4.1-like protein 4A | NM_022140 | 0.34 | 0.56 |
| Zinc ion binding | ||||
| MMP7 | Matrilysin | NM_002423 | 2.16 | 1.94 |
| CA11 | Carbonic anhydrase-related protein 11 | NM_001217 | 0.62 | 0.55 |
| Methyltransferase activity | ||||
| METTL7A | Methyltransferase-like protein 7A | NM_014033 | 0.26 | 0.67 |