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Effects of PAMK on CD28 and downstream signal pathway in lymphocytes treated with siCD28. Relative mRNA expression of (A) CD28, (B) IP3R, (C) PLCγ-1, (D) NFAT, and (E) AP-1. Data are expressed as the means ± SD, n = 6.*p < 0.05, **p < 0.01, ***p < 0.001, compared with the NC group; # p < 0.05, ## p < 0.01, ### p < 0.001, compared with the siCD28 group.
