Fig. 3.

D1DR/D2DR antagonists-induced down-regulation of phosphorylated MAPKs expression could be reversed by NMDAR agonist. (a, b, and c) The expression of p-p38, p-ERK, and p-JNK in TCI rats after coadministration of SCH 23,390 with NMDA. (d, e, and f) The expression of p-p38, p-JNK, and p-ERK in TCI rats after coadministration of L-741,626 with NMDA (n = 4, # P < 0.05, ## P < 0.01, compared with Sham + Vehicle group, *P < 0.05, **P < 0.01, compared with TCI + Vehicle group, & P < 0.05, && P < 0.01, compared with TCI + SCH 23390/L-741,626 group, p-MAPKs/MAPKs is the expression of (p- MAPKs/GAPDH)/(MAPKs/GAPDH)).