Table 1.

Laboratory finding studies in COVID‐19 patients

Subject of study	Region study	Sample size	Main findings	References
Laboratory data analysis of novel coronavirus (COVID‐19) screening in 2510 patients	Clinic of Xiangya Second Hospital of Central South University	2510	The count of monocyte increases in COVID‐19 patients compared to influenza patients.	[9]
Viral load dynamics and disease severity in patients infected with SARS‐CoV‐2 in Zhejiang province, China, January‐March 2020: retrospective cohort study	Designated hospital for patients with COVID‐19 in Zhejiang province, China	96	Observed no significant quantitative difference in monocyte level between the COVID‐19 patients and healthy individuals	[39]
Pathogenic T cells and inflammatory monocytes incite inflammatory storms in severe COVID‐19 patients	Review		observed that GM‐CSF + Th1 cells and CD14+ CD16+ monocytes accelerated the immune response and exacerbated the COIVID‐19 disease through over expression of IL‐6.	[40]
Abnormalities of peripheral blood system in patients with COVID‐19 in Wenzhou, China	Wenzhou	116	Observed that there is significant difference between COVID‐19 patients and the control group in terms of monocyte count, the severity of the disease, and ICU admission requirement.	[41]
COVID‐19 infection induces readily detectable morphological and inflammation‐related phenotypic changes in peripheral blood monocytes, the severity of which correlate with patient outcome	Multicenter Study	28	Stated that the sequential detection and monitoring of this subset of inflammatory monocytes using flow cytometry can help determine the prognosis of COVID‐19 patients	[27]
Morphological anomalies of circulating blood cells in COVID‐19	Parallel COVID‐19 hospital at Fondazione Policlinico A. Gemelli of Rome, a	40	They observed that the absolute neutrophil count mostly increased in the first few days of hospitalization, while decreased slightly before or immediately after the treatment	[42]
Hematological findings and complications of COVID‐19	Review Article		They found that neutrophilic leukocytosis was associated with an increased risk of acute respiratory syndrome, risk of death, and elevated troponin level.	[29]
Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID‐19): a meta‐analysis	Meta‐analysis		They confirmed that neutrophil count was significantly higher in non‐survivors COVID‐19 patients compared to survivors.	[46]
Patients of COVID‐19 may benefit from sustained Lopinavir‐combined regimen and the increase of Eosinophil may predict the outcome of COVID‐19 progression	Xixi hospital in Hangzhou, China	10	Increasing eosinophils may be an indicator of COVID‐19 improvement.	[49]
Evaluation of Hepatic Enzymes Changes and Association with Prognosis in COVID‐19 Patients	Mazandaran University of Medical Sciences’ hospitals	93	Hemoglobin levels were lower in COVID‐19 patients than in the control group, although the difference was not statistically significant	[52]
Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID‐19)	Seventh Hospital of Wuhan City, China	187	observed that hemoglobin levels were not significantly different in COVID‐19 patients with a history of myocardial injury and elevated TnT levels compared with those with normal TnT levels	[53]
Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID‐19) infections: A meta‐analysis	Meta‐analysis		A relationship between platelet count at the time of hospitalization and the severity of the disease was observed	[58]
Association between platelet parameters and mortality in coronavirus disease 2019: Retrospective cohort study	Central Hospital of Wuhan	383	Baseline platelet levels and changes were associated with subsequent mortality. Monitoring platelets during hospitalization may be important in the prognosis of patients with coronavirus disease in 2019.	[57]