Figure 4.

The HLADR^low CD9^low monocyte population in severe COVID‐19 releases neutrophil chemokines in the lung. In silico reanalysis of publicly available single cell RNA sequencing data published by Liao et al.¹⁴ A, Top eight up‐ and downregulated GO‐BP pathways of severe versus mild cases for monocytic macrophages in bronchoalveolar lavage. Fold enrichment is relative to mild cases. B, Volcano plot of relative fold change of severe versus mild cases for monocytic macrophages. CXCL8, CCL2, CCL3, CCL4, CCL7, CXCL3, CCL4L2, and CCL3L1, when significantly increased, are marked in red and annotated. C, Dot plots of average and percentage expression for different cell groups