Table 2.
Cyclosporine group n = 105 |
Control group n = 104 |
P* | |||
---|---|---|---|---|---|
Improvement | Death | Improvement | Death | ||
Mild CT: No. (%) a 43 (100) |
9 (20) α = 1 – |
0 (0) – β = 0 |
31 (72) α = 0.91 – |
3(8) – β = 0.09 |
0.82 0.17 |
Moderate CT: No. (%) 79 (100) |
41 (52) α = 0.84 – |
7 (8.8) – β = 0.16 |
25 (32) α = 0.89 – |
6 (7.2) – β = 0.1 |
0.71 0.28 |
Severe CT: No. (%) 87 (100) |
32 (37) α = 0.66 – |
16 (18) – β = 0.34 |
11 (12.6) α = 0.28 – |
28 (32.4) – β = 0.72 |
0.001 0.0001 |
Ground glass CT category: No. (%) b 52 (100) |
16 (30.5) α = 0.94 – |
1 (2) – β = 0.06 |
33 (63.5) α = 0.94 – |
2(4) – β = 0.06 |
0.49 0.5 |
Crazy paving CT category: No. (%) 118 (100) |
52 (44) α = 0.78 – |
15(13) – β = 0.22 |
26 (22) α = 0.51 – |
25 (21) – β = 0.49 |
0.001 0.001 |
Consolidation CT category: No. (%) 39 (100) |
14 (36) α = 0.66 – |
7 (18) – β = 0.33 |
8 (20.5) α = 0.45 – |
10 (25.5) – β = 0.55 |
0. 08 0. 08 |
CALL Score < 6 c No. (%) 43 (100) |
19 (44) α = 0.95 – |
1 (2.5) – β = 0.05 |
22 (51) α = 0.96 – |
1 (2.5) – β = 0.04 |
0.45 0.54 |
CALL Score 7–9: No. (%) 92 (100) |
42 (45.6) α = 0.8 – |
10 (10.8) – β = 0.2 |
29 (31.5) α = 0.725 – |
11 (11.8) – β = 0.275 |
0. 82 0.17 |
CALL Score 10–13: No. (%) 74 (100) |
21 (28.3) α = 0.636 – |
12 (16.2) – β = 0.364 |
16 (21.6) α = 0.39 – |
25 (33.9) – β = 0.61 |
0.01 0.01 |
α = improvement probability, β = death probability (* statistical significance was considered P < 0.05 for the difference between the experimental group and the control group).
Lung CT severity score: 1 to 5 points (mild damage), 6 to 14 points (moderate damage) and 15 to 25 points (severe damage).
CT category: ground glass (initial phase), crazy paving (disease progression – inflammatory phase), and consolidation (advanced disease‐extensive inflammatory infiltrate of the lung parenchyma).
CALL Score (comorbidities, age over 60 years, lactate dehydrogenase and lymphopenia): 1 to 6 points (low risk), 7 to 9 points (10 to 40% probability of progression) and 10 to 13 points (> 50% probability of progression).