. 2021 Feb 2;289(6):906–920. doi: 10.1111/joim.13223

Table 2.

Improvement or death outcome in the patients grouped in the intervention and control subsets. The patients were classified according to the index of severity of lung damage by CT, CT category and probability of progression

	Cyclosporine group n = 105	Control group n = 104	P*
Mild CT: No. (%) ^a 43 (100)	9 (20) α = 1 –	0 (0) – β = 0	31 (72) α = 0.91 –	3(8) – β = 0.09	0.82 0.17
Moderate CT: No. (%) 79 (100)	41 (52) α = 0.84 –	7 (8.8) – β = 0.16	25 (32) α = 0.89 –	6 (7.2) – β = 0.1	0.71 0.28
Severe CT: No. (%) 87 (100)	32 (37) α = 0.66 –	16 (18) – β = 0.34	11 (12.6) α = 0.28 –	28 (32.4) – β = 0.72	0.001 0.0001
Ground glass CT category: No. (%) ^b 52 (100)	16 (30.5) α = 0.94 –	1 (2) – β = 0.06	33 (63.5) α = 0.94 –	2(4) – β = 0.06	0.49 0.5
Crazy paving CT category: No. (%) 118 (100)	52 (44) α = 0.78 –	15(13) – β = 0.22	26 (22) α = 0.51 –	25 (21) – β = 0.49	0.001 0.001
Consolidation CT category: No. (%) 39 (100)	14 (36) α = 0.66 –	7 (18) – β = 0.33	8 (20.5) α = 0.45 –	10 (25.5) – β = 0.55	0. 08 0. 08
CALL Score < 6 ^c No. (%) 43 (100)	19 (44) α = 0.95 –	1 (2.5) – β = 0.05	22 (51) α = 0.96 –	1 (2.5) – β = 0.04	0.45 0.54
CALL Score 7–9: No. (%) 92 (100)	42 (45.6) α = 0.8 –	10 (10.8) – β = 0.2	29 (31.5) α = 0.725 –	11 (11.8) – β = 0.275	0. 82 0.17
CALL Score 10–13: No. (%) 74 (100)	21 (28.3) α = 0.636 –	12 (16.2) – β = 0.364	16 (21.6) α = 0.39 –	25 (33.9) – β = 0.61	0.01 0.01

Cyclosporine group

n = 105

Control group

n = 104

Improvement

Death

Improvement

Death

Mild CT: No. (%) ^a

43 (100)

9 (20)

α = 1

–

0 (0)

–

β = 0

31 (72)

α = 0.91

–

3(8)

–

β = 0.09

0.82

0.17

Moderate CT: No. (%)

79 (100)

41 (52)

α = 0.84

–

7 (8.8)

–

β = 0.16

25 (32)

α = 0.89

–

6 (7.2)

–

β = 0.1

0.71

0.28

Severe CT: No. (%)

87 (100)

32 (37)

α = 0.66

–

16 (18)

–

β = 0.34

11 (12.6)

α = 0.28

–

28 (32.4)

–

β = 0.72

0.001

0.0001

Ground glass CT category: No. (%) ^b

52 (100)

16 (30.5)

α = 0.94

–

1 (2)

–

β = 0.06

33 (63.5)

α = 0.94

–

2(4)

–

β = 0.06

0.49

0.5

Crazy paving CT category: No. (%)

118 (100)

52 (44)

α = 0.78

–

15(13)

–

β = 0.22

26 (22)

α = 0.51

–

25 (21)

–

β = 0.49

0.001

Consolidation CT category: No. (%)

39 (100)

14 (36)

α = 0.66

–

7 (18)

–

β = 0.33

8 (20.5)

α = 0.45

–

10 (25.5)

–

β = 0.55

0. 08

CALL Score < 6 ^c

No. (%)

43 (100)

19 (44)

α = 0.95

–

1 (2.5)

–

β = 0.05

22 (51)

α = 0.96

–

1 (2.5)

–

β = 0.04

0.45

0.54

CALL Score 7–9:

No. (%)

92 (100)

42 (45.6)

α = 0.8

–

10 (10.8)

–

β = 0.2

29 (31.5)

α = 0.725

–

11 (11.8)

–

β = 0.275

0. 82

0.17

CALL Score 10–13:

No. (%)

74 (100)

21 (28.3)

α = 0.636

–

12 (16.2)

–

β = 0.364

16 (21.6)

α = 0.39

–

25 (33.9)

–

β = 0.61

0.01

α = improvement probability, β = death probability (* statistical significance was considered P < 0.05 for the difference between the experimental group and the control group).

^{^a}

Lung CT severity score: 1 to 5 points (mild damage), 6 to 14 points (moderate damage) and 15 to 25 points (severe damage).

^{^b}

CT category: ground glass (initial phase), crazy paving (disease progression – inflammatory phase), and consolidation (advanced disease‐extensive inflammatory infiltrate of the lung parenchyma).

^{^c}

CALL Score (comorbidities, age over 60 years, lactate dehydrogenase and lymphopenia): 1 to 6 points (low risk), 7 to 9 points (10 to 40% probability of progression) and 10 to 13 points (> 50% probability of progression).