TABLE 1.
Number of the synonymous and nonsynonymous coding SNPs and the SNPs from the untranslated regions and intron of the genes coding cytokines and cytokine receptors that were high plasma concentrations in COVID‐19 patients
| Gene name | 3′‐UTR | 5′‐UTR | Intron upstream and downstream transcript variant | Synonymous variant | Missense variant |
|---|---|---|---|---|---|
| Cytokine genes | |||||
| CCL2 | 1 | — | 2 | 1 | — |
| CCL3 | 2 | — | 7 | 1 | — |
| CCL4 | — | — | 29 | 1 | 2 |
| CSF2 | — | — | 8 | — | 1 |
| CSF3 | 2 | — | 7 | 1 | — |
| CXCL8 | 2 | — | 6 | — | — |
| CXCL10 | 3 | — | 17 | — | — |
| IFNG | — | — | 9 | — | — |
| IL1B | — | 1 | 10 | — | — |
| IL1RN | 2 | 4 | 143 | 2 | — |
| IL7 | 15 | — | 109 | — | — |
| IL9 | — | — | 6 | — | — |
| IL10 | 1 | 1 | 12 | — | — |
| PDGFB | — | 1 | 63 | — | — |
| TNF | — | — | 2 | — | — |
| VEGFA | 2 | 1 | 40 | — | — |
| Cytokine receptor genes | |||||
| CCR1 | — | — | 4 | — | — |
| CCR2 | 3 | 1 | 15 | — | 1 |
| CCR4 | 2 | — | 5 | — | — |
| CCR5 | 2 | 2 | 14 | — | — |
| CSF2RA | 9 | 1 | 420 | 1 | — |
| CSF3R | — | 1 | 22 | 2 | — |
| CXCR1 | — | — | 1 | — | — |
| CXCR2 | 3 | 1 | 15 | 1 | — |
| CXCR3 | — | — | 2 | — | — |
| FLT1 | 16 | — | 254 | 2 | — |
| IFNGR1 | — | 3 | 16 | — | — |
| IFNGR2 | 2 | 3 | 59 | — | 1 |
| IL1R1 | 3 | 7 | 260 | — | — |
| IL1R2 | 1 | 17 | 110 | — | — |
| IL7R | 11 | — | 53 | — | 3 |
| IL9R | — | — | 30 | — | — |
| IL10RA | 1 | — | 17 | — | 1 |
| IL10RB | 4 | 4 | 85 | — | 1 |
| KDR | — | 1 | 89 | — | 2 |
| TNFRSF1A | 1 | 1 | 22 | 1 | — |
| TNFRSF1B | 5 | — | 47 | 1 | 1 |