TABLE 2.
SIFT, PolyPhen‐2 and I‐Mutant‐2.0 results of missense SNPs of genes encoding the cytokines and cytokine receptors that was elevated in COVID‐19 patients
| Gene name | Gene ID | SNP | Allele change | Amino acid change | SIFT prediction | Polyphen‐2 prediction | I‐Mutant‐2.0 prediction |
|---|---|---|---|---|---|---|---|
| Cytokine genes | |||||||
| CCL4 | ENSG00000129277 | rs1049807 | A/G | N41S E79E | Tolerated | ||
| CCL4 | ENSG00000129277 | rs1719152 | T/A | S80T N41K | Tolerated | ||
| CSF2 | ENSG00000164400 | rs25882 | T/C | I117T | Tolerated | ||
| Cytokine receptor genes | |||||||
| CCR2 | ENSG00000121807 | rs1799864 | G/A | V64I | Tolerated | ||
| IFNGR2 | ENSG00000159128 | rs9808753 | A/G | Q83R, Q64R | Tolerated | ||
| IL7R | ENSG00000168685 | rs1494558 | T/C | I66T | Tolerated | ||
| IL7R | ENSG00000168685 | rs6897932 | C/T | T244I | Tolerated | ||
| IL7R | ENSG00000168685 | rs1494555 | G/A | V138I | Tolerated | ||
| IL10RA | ENSG00000110324 | rs2229113 | A/G | R351G R331G R202G | Tolerated | ||
| TNFRSF1B | ENSG00000028137 | rs1061622 | T/G | M196R | Tolerated | ||
| IL10RB | ENSG00000243646 | rs2834167 | A/G | K47E | Tolerated | ||
| KDR | ENSG00000128052 | rs1870377 | T/A | Q472H | Deleterious | Benign | Decrease stability |
| KDR | ENSG00000128052 | rs2305948 | C/T | V297I | Tolerated | ||