TABLE 3.
miRSNP results of SNPs' miRNA binding efficiency for cytokine and cytokine receptor genes
| Gene | SNP | Allele | Effect | |||
|---|---|---|---|---|---|---|
| Decrease | Enhance | Create | Break | |||
| Cytokine genes | ||||||
| CCL2 | rs13900 | C | hsa‐miR‐3163 |
hsa‐miR‐374a‐5p hsa‐miR‐374b‐5p |
hsa‐miR‐4761‐5p hsa‐miR‐624‐3p |
|
| CCL3 | rs8951 | G | hsa‐miR‐5002‐3p | hsa‐miR‐4672 |
hsa‐miR‐3929 hsa‐miR‐4419b hsa‐miR‐4438 hsa‐miR‐4478 hsa‐miR‐4502 |
|
| rs1063340 | G |
hsa‐miR‐3179 hsa‐miR‐3202 hsa‐miR‐4716‐3p hsa‐miR‐4723‐5p hsa‐miR‐4747‐5p hsa‐miR‐5196‐5p hsa‐miR‐5698 |
hsa‐miR‐1292 | |||
| CSF3 | rs2827 | C | hsa‐miR‐3653 | hsa‐miR‐3658 | hsa‐miR‐548ad | |
| rs1042658 | C | hsa‐miR‐2355‐5p | hsa‐miR‐5586‐5p | hsa‐miR‐1247‐5p | ||
| IL8 | rs1126647 | A | hsa‐miR‐944 | |||
| CXCL10 | rs3921 | C | hsa‐miR‐5002‐5p |
hsa‐miR‐509‐3p hsa‐miR‐591 |
||
| rs34836828 | Deletion | hsa‐miR‐145‐3p | ||||
| VEGFA | rs3025040 | C |
hsa‐miR‐199a‐5p hsa‐miR‐199b‐5p hsa‐miR‐4676‐5p hsa‐miR‐575 |
|||
| rs10434 | A |
hsa‐miR‐4727‐5p |
hsa‐miR‐3677‐5p |
hsa‐miR‐3545‐5p hsa‐miR‐5693 hsa‐miR‐660‐3p |
||
| Cytokine receptor genes | ||||||
| CCR2 | rs743660 | A | hsa‐miR‐4786‐3p | |||
| CCR5 | rs746492 | T | hsa‐miR‐5007‐3p |
hsa‐miR‐4524a‐3p hsa‐miR‐589‐3p |
hsa‐miR‐3133 | |
| CXCR2 | rs1126579 | C | hsa‐miR‐5193 | hsa‐miR‐138–1‐3p |
hsa‐miR‐516a‐3p hsa‐miR‐516b‐3p |
|
| rs1126580 | A | hsa‐miR‐4524b‐3p | hsa‐miR‐5096 | |||
| FLT1 | rs2296283 | C |
hsa‐miR‐3135b hsa‐miR‐3940‐3p |
hsa‐miR‐1538 hsa‐miR‐4731‐5p hsa‐miR‐4745‐3p |
||
| rs2296284 | C |
hsa‐miR‐3943 hsa‐miR‐4313 |
hsa‐miR‐4293 | hsa‐miR‐1234 | ||
| rs3209052 | A |
hsa‐miR‐4789‐3p hsa‐miR‐582‐5p |
||||
| rs3751397 | T | hsa‐miR‐3662 |
hsa‐miR‐548a‐3p hsa‐miR‐548ar‐3p hsa‐miR‐548e hsa‐miR‐548f |
|||
| rs7326277 | G |
hsa‐miR‐193b‐5p hsa‐miR‐4446‐5p |
hsa‐miR‐193a‐5p | |||
| rs7337610 | G | hsa‐miR‐589‐3p | hsa‐miR‐448 | |||
| rs9551465 | T | hsa‐miR‐223‐5p | ||||
| rs17086617 | G | hsa‐miR‐224‐5p | ||||
| rs35779457 | Deletion | hsa‐miR‐876‐3p | hsa‐miR‐4495 | |||
| rs55875014 | G |
hsa‐miR‐3916 hsa‐miR‐5197‐3p |
hsa‐miR‐3065‐5p hsa‐miR‐3529‐3p hsa‐miR‐3928 |
|||
| rs56340749 | Deletion |
hsa‐miR‐4446‐3p hsa‐miR‐4498 |
hsa‐miR‐194‐3p hsa‐miR‐5001‐5p |
hsa‐miR‐1225‐5p | ||
| rs56791288 | Deletion | hsa‐miR‐4531 | ||||
| IFNGR2 | rs1059293 | C | hsa‐miR‐493‐5p | |||
| IL1R1 | rs2110726 | G |
hsa‐miR‐4534 hsa‐miR‐4802‐5p |
|||
| rs3732131 | G | hsa‐miR‐4762‐3p | ||||
| rs3917324 | C |
hsa‐miR‐4716‐5p hsa‐miR‐4776‐3p hsa‐miR‐4781‐3p |
hsa‐miR‐191‐3p hsa‐miR‐604 hsa‐miR‐647 |
hsa‐miR‐1587 hsa‐miR‐378g hsa‐miR‐4492 hsa‐miR‐4498 hsa‐miR‐4505 hsa‐miR‐5001‐5p hsa‐miR‐762 |
||
| IL10RB | rs1058867 | A | hsa‐miR‐219–1‐3p | hsa‐miR‐377‐5p | ||
| rs3171425 | A | hsa‐miR‐328 |
hsa‐miR‐1282 hsa‐miR‐4655‐3p |
|||
| rs8178562 | A |
hsa‐miR‐4252 hsa‐miR‐5008‐3p |
hsa‐miR‐218‐5p hsa‐miR‐328 hsa‐miR‐636 |
|||
| TNFRSF1B | rs3397 | C | hsa‐miR‐3126‐5p | hsa‐miR‐5581‐5p |
hsa‐miR‐329 hsa‐miR‐362‐3p |
hsa‐miR‐122‐3p |
| rs1061624 | A/C/G | hsa‐miR‐3188 | hsa‐miR‐5003‐5p | |||
|
C, T→A T→G |
hsa‐miR‐3692‐3p | |||||
| G→C,A | hsa‐miR‐3692‐3p | |||||
| C | hsa‐miR‐922 | hsa‐miR‐523‐3p | ||||
| A | hsa‐miR‐922 | hsa‐miR‐523‐3p |
hsa‐miR‐639 hsa‐miR‐720 |
|||
| rs1061628 | A | hsa‐miR‐4715‐5p | hsa‐miR‐3680‐3p | |||
| C | hsa‐miR‐4715‐5p | |||||
| rs5746065 | A | hsa‐miR‐4786‐3p |
hsa‐miR‐1299 hsa‐miR‐671‐5p |
hsa‐miR‐4731‐5p hsa‐miR‐486‐3p |
hsa‐miR‐5589‐5p | |