Fig. 4.

No effect of smoking history on lung damage. (a) Average scores for each of five lobes. There was neither interaction between smoking and lobe nor significant difference between nonsmoker and smoker for any of the lobe based on Bonferroni post‐tests. (b) Average of five lobes. (c) Illness day (iDay) versus total score of five lobes. Each dot represents a patient. Linear correlation statistics was for the first three weeks (grey arrow) after onset (iDay = 0, blue arrow). (d) and (e) Time course of lung (five lobes together) damage score in 95 nonsmokers and 40 smokers. Each curve or line is for one patient; iDay, illness day (0 for onset day), patients with single CT scans or outside the iDay range were not shown. Red asterisks, representative CT images from a nonsmoker and a smoker are shown in Figure S1. (f) Rate of change in lung damage score on average (upper left panel) and in each of five lobes. iDay = 0 as onset; positive score, disease progression; negative score, lung recovering; each dot represents a rate: green, nonsmoker; red, smoker.