Table 5. Multivariate analysis of factors considered prognostic of OS in patients with rectal cancer received NACRT using Cox proportional hazard model.

	OS
Factors	Univariate			Multivariate
	HR	95%CI	P value	HR	95%CI	P value
Sex (female/male)	0.986	0.965–1.008	0.203	-	-	-
Age (≥60 vs. <60)	0.293	0.179–0.481	0.001	0.903	0.015–0.255	0.001
ypTumor size (cm)	1.460	0.899–2.371	0.126	-	-	-
Histological type well/poor-differentiated	1.620	0.997–2.633	0.052	-	-	-
TRG score (0-1 vs. ≥2)	0.659	0.402–1.081	0.099	-	-	-
ECOG score (0 vs. ≥1)	1.213	0.717–2.052	0.471	-	-	-
Tumor location low versus middle-high	1.836	1.085–3.108	0.054	-	-	-
Mile’s versus Dixon	1.384	0.852–2.249	0.190	-	-	-
pT stage (T3 vs. T4)	0.915	0.557–1.506	0.728	-	-	-
pN stage (N0 vs. N≥1)	4.215	2.546–6.977	<0.001	5.113	3.757–8.745	0.083
pTNM stage (II vs. III-IV)	4.630	2.729–7.855	<0.001	9.566	2.303–39.737	0.002
Neurological invasion (yes vs. no)	1.922	1.136–3.254	0.150	-	-	-
Vascular invasion (yes vs. no)	2.330	1.430–3.795	0.001	9.389	3.561–16.992	0.079
Pre-operative NLR level	1.150	1.005–1.317	0.043	2.501	1.277–4.383	0.067
Post-operative NLR level	0.935	0.818–1.068	0.322	-	-	-
Pre-operative PLR level	0.957	0.903–1.014	0.139	-	-	-
Post-operative PLR level	1.032	0.943–1.131	0.491	-	-	-
Pre-operative LMR level	1.221	1.089–1.370	0.001	2.442	1.478–3.780	0.167
Post-operative LMR level	1.347	1.172–1.549	<0.001	2.388	1.505–3.788	<0.001
Pre-RDW level	1.160	1.025–1.313	0.025	0.64	0.393–1.040	0.072
Pre-operative RDW level	1.062	0.996–1.133	0.065	-	-	-
Post-operative RDW level	1.578	1.373–1.815	<0.001	1.647	1.342–2.201	<0.001

Abbreviations: LMR, lymphocyte–monocyte ratio; NLR, neutrophil–lymphocyte ratio; PLR, platelet–lymphocyte ratio; RDW, red cell distribution width.