Table 1.

Patient background and clinical characteristics at ICU in 57 patients treated for severe COVID‐19 according to acute kidney injury (AKI) stage. Values presented as mean ± SD or percent of N

	No AKI	KDIGO 1	KDIGO 2	KDIGO 3
N	6	9	29	13
Age (y)	53 ± 22	63 ± 9	56 ± 15	67 ± 6
Sex (% female)	33	44	24	0
Body weight (kg)	78 ± 14	77 ± 16	89 ± 14	93 ± 27
BMI	25 ± 3	26 ± 8	30 ± 5	32 ± 7
Pulmonary disease (%)	17	33	31	8
Hypertension (%)	33	56	52	69
Heart failure (%)	0	11	3	0
Ischemic heart disease (%)	0	22	7	15
Malignant disease (%)	0	11	7	8
Diabetes (%)	0	44	28	31
ACEi/ARB treatment (%)	17	56	41	38
Baseline P‐Creatinine (µmol/L)	69 ± 14	69 ± 25	73 ± 21	80 ± 13
Elevated baseline P‐Creatinine (%)	0	11	21	8
At ICU admission
SAPS 3 score	47 ± 5	58 ± 9	51 ± 10	55 ± 9
Glasgow coma scale 15 (%)	80	67	79	92
Heart rate	81 ± 9	96 ± 26	91 ± 13	86 ± 15
Mean arterial pressure	92 ± 14	99 ± 20	92 ± 17	92 ± 15
COVID day	11 ± 4	11 ± 4	11 ± 3	10 ± 3
P‐Creatinine at arrival (µmol/L)	79 ± 18	81 ± 34	83 ± 38	244 ± 443
Invasive ventilation (%)	0	33	17	8
Vasopressor treatment (%)	0	22	3	8
During ICU stay
Highest P‐Creatinine (µmol/L)	89 ± 20	95 ± 28	116 ± 54	441 ± 410
Invasive ventilation (%)	17	67	69	92
30 day mortality (%)	17	33	17	54
Total volume of fluids at end of ICU day 1 (mL/kg)	72 ± 57	59 ± 22	54 ± 23	50 ± 15
Cumulative fluid balance at end of ICU day 1 (mL/kg)	27 ± 21	13 ± 19	19 ± 20	16 ± 19
Positive cumulative fluid balance at end of ICU day 1 (%)	83	89	76	69

Conversion factors for units: plasma creatinine in μmol/L to mg/dL, ×0.0113.

Abbreviations: ACEi, angiotensin‐converting enzyme inhibitors; ARB, angiotensin II receptor blockers; BMI, body mass index; eGFR, estimated glomerular filtration rate; ICU, intensive care unit; SAPS 3, simplified acute physiological score III.