Table 5.
Levels and proportions of urinary biomarkers at ICU admission characteristics in different acute kidney injury (AKI) stages defined by KDIGO urine output criteria only. N = 48
| No AKIUO | KDIGOUO 1 | KDIGOUO 2 | KDIGOUO 3 | |
|---|---|---|---|---|
| N | 8 | 8 | 29 | 3 |
| U‐Albumin (mg/mmol) | 19 ± 18 | 39 ± 70 | 9 ± 10 | 14 ± 17 |
| Microalbuminuria (%) | 75 | 75 | 69 | 100 |
| Severe albuminuria (%) | 25 | 25 | 7 | 33 |
| U‐Cystatin‐CCorr (mg/mmol)††† | 0.3 ± 0.3** | 0.3 ± 0.2** | 0.1 ± 0.1** | 0.6 ± 0.7 |
| U‐Cystatin C (mg/L) | 1.2 ± 0.8 | 1.5 ± 1 | 0.8 ± 0.5 | 1.7 ± 1 |
| U‐Cystatin‐C > 0.414 mg/L (%) | 88 | 88 | 62 | 100 |
| U‐NGAL (ng/mL) | 199 ± 264 | 211 ± 393 | 58 ± 77 | 172 ± 247 |
| U‐NGALCorr (ng/mmol)† | 53 ± 75 | 54 ± 84 | 6 ± 7 | 89 ± 146 |
| U‐NGAL > 100 (ng/mL) (%)† | 50* | 38 | 10* | 33 |
| U‐KIM‐1 (ng/L) | 2.1 ± 2.2 | 2.7 ± 3 | 4.8 ± 3.6 | 1.7 ± 1.7 |
| U‐KIM‐1Corr (ng/mg) | 4 ± 3.7 | 4.5 ± 4 | 5.9 ± 4.9 | 2.8 ± 1 |
| U‐KIM‐1 > 2.37 ng/mg (%) | 63 | 50 | 76 | 67 |
| U‐TIMP2 (ng/mL) | 19 ± 31 | 7 ± 5 | 10 ± 7 | 6 ± 6 |
| U‐TIMP2Corr (ng/mg) | 52 ± 104 | 15 ± 12 | 9 ± 4 | 12 ± 11 |
| U‐TIMP2 > 7.58 ng/mL (%) | 38 | 25 | 66 | 33 |
Abbreviations: KIM‐1, Kidney Injury Molecule 1; NGAL, Neutrophil Gelatinase‐Associated Lipocalin; TIMP‐2, Plasma Tissue Inhibitor of MetalloProteinase 2.
Indicates difference between all groups († P < .05, ††† P < .0001).
Indicates difference between groups (*P < .05, **P < .01 between KDIGOuo 2 and KDIGOuo 0 + 1, respectively).