Figure 5.

Influence of glucocorticoid treatment on the expression of ACE2 and inflammatory cytokines. CRSwNP patients received a 2‐week course of oral glucocorticoid. Nasal polyp tissues were collected before (Baseline) and after glucocorticoid treatment (GC‐treated). The expression of ACE2 (A), IFNG (B), IL5 (C) and IL17A (D) in the tissue was detected by RNA sequencing. N = 13 for ECRSwNP patients, n = 8 for nonECRSwNP patients. *P < .05. CRSwNP, chronic rhinosinusitis with nasal polyps; ECRSwNP, eosinophilic CRSwNP; nonECRSwNP, noneosinophilic CRSwNP; ACE2, angiotensin‐converting enzyme 2; RPLP0, ribosomal protein lateral stalk subunit P0; IL, interleukin; IFNG, interferon gamma; FPKM, fragments per kilo‐base of exon per million fragments mapped; GC, glucocorticoid; n.s., no significance