Figure 2.

Tris DBA enhanced autophagy induction and inhibited NLRP3 inflammasome activation in IgAN mice. The expression levels of (A) NLRP3, IL‐1β and caspase‐1 in real‐time PCR analysis and (B)NLRP3, IL‐18, IL‐1β and caspase‐1 in Western blot analysis and (C) Semiquantitative analysis. D, Renal LC3B I/II and ATG5 levels after administration of 30 mg/kg Tris DBA to untreated WT mice assessed by Western blot analysis and (E) semiquantitative analysis. F, Renal SIRT1 and SIRT3 levels in Western blot analysis and (G) semiquantitative analysis. Bars show the mean ± SEM results in 7 mice per group. **P < .01, ***P < .005, ****P < .001