Table 2.
The overlapped genes between the target genes of active ingredients and NAFLD-related genes.
| No. | Uniprot ID | Gene ID | Gene symbol | Gene full name |
|---|---|---|---|---|
| 1 | P54710 | 486 | FXYD2 | FXYD domain containing ion transport regulator 2 |
| 2 | P06396 | 2934 | GSN | Gelsolin |
| 3 | P28472 | 2562 | GABRB3 | Gamma-aminobutyric acid type A receptor Beta3 subunit |
| 4 | P07996 | 7057 | THBS1 | Thrombospondin 1 |
| 5 | P54289 | 781 | CACNA2D1 | Calcium voltage-gated channel auxiliary subunit Alpha2delta 1 |
| 6 | P04818 | 7298 | TYMS | Thymidylate synthetase |
| 7 | P17302 | 2697 | GJA1 | Gap junction protein alpha 1 |
| 8 | P55011 | 6558 | SLC12A2 | Solute carrier family 12 member 2 |
| 9 | P07585 | 1634 | DCN | Decorin |
| 10 | P08729 | 3855 | KRT7 | Keratin 7 |
| 11 | P14210 | 3082 | HGF | Hepatocyte growth factor |
| 12 | P13569 | 1080 | CFTR | CF Transmembrane conductance regulator |
| 13 | Q96SL4 | 2882 | GPX7 | Glutathione peroxidase 7 |
| 14 | P13500 | 6347 | CCL2 | C-C motif chemokine ligand 2 |
| 15 | O94925 | 2744 | GLS | Glutaminase |
| 16 | P21802 | 2263 | FGFR2 | Fibroblast growth factor receptor 2 |
| 17 | Q99584 | 6284 | S100A13 | S100 calcium binding protein A13 |
| 18 | Q13133 | 10062 | NR1H3 | Nuclear receptor subfamily 1 group H member 3 |
| 19 | P13716 | 210 | ALAD | Aminolevulinate dehydratase |
| 20 | P82251 | 11136 | SLC7A9 | Solute carrier family 7 member 9 |
| 21 | Q8N159 | 162417 | NAGS | N-Acetylglutamate synthase |
| 22 | P21549 | 189 | AGXT | Alanine-glyoxylate and serine-pyruvate aminotransferase |
| 23 | P34896 | 6470 | SHMT1 | Serine hydroxymethyltransferase 1 |
| 24 | Q08828 | 107 | ADCY1 | Adenylate cyclase 1 |
| 25 | O43708 | 2954 | GSTZ1 | Glutathione S-transferase zeta 1 |
| 26 | P51570 | 2584 | GALK1 | Galactokinase 1 |
| 27 | P15104 | 2752 | GLUL | Glutamate-ammonia ligase |
| 28 | Q14749 | 27232 | GNMT | Glycine N-methyltransferase |
| 29 | P36222 | 1116 | CHI3L1 | Chitinase 3 like 1 |
| 30 | Q8TED1 | 493869 | GPX8 | Glutathione peroxidase 8 (putative) |
| 31 | P11137 | 4133 | MAP2 | Microtubule associated protein 2 |
| 32 | P00750 | 5327 | PLAT | Plasminogen activator, tissue type |
| 33 | Q9H2S1 | 3781 | KCNN2 | Potassium calcium-activated channel subfamily N member 2 |
| 34 | P04181 | 4942 | OAT | Ornithine aminotransferase |
| 35 | Q07869 | 5465 | PPARA | Peroxisome proliferator activated receptor alpha |
| 36 | P01130 | 3949 | LDLR | Low density lipoprotein receptor |
| 37 | P09488 | 2944 | GSTM1 | Glutathione S-transferase mu 1 |
| 38 | P09211 | 2950 | GSTP1 | Glutathione S-transferase pi 1 |
| 39 | Q03181 | 5467 | PPARD | Peroxisome proliferator activated receptor delta |
| 40 | P30711 | 2952 | GSTT1 | Glutathione S-transferase theta 1 |
| 41 | P08263 | 2938 | GSTA1 | Glutathione S-transferase alpha 1 |
| 42 | P03956 | 4312 | MMP1 | Matrix metallopeptidase 1 |
| 43 | Q9P2W7 | 27087 | B3GAT1 | Beta-1,3-glucuronyltransferase 1 |
| 44 | O60674 | 3717 | JAK2 | Janus kinase 2 |
| 45 | P08700 | 3562 | IL3 | Interleukin 3 |
| 46 | P12821 | 1636 | ACE | Angiotensin I converting enzyme |
| 47 | P00734 | 2147 | F2 | Coagulation factor II, thrombin |
| 48 | Q8WTV0 | 949 | SCARB1 | Scavenger receptor class B member 1 |
| 49 | P06576 | 506 | ATP5F1B | ATP synthase F1 subunit beta |
| 50 | O14594 | 1463 | NCAN | Neurocan |
| 51 | P24298 | 2875 | GPT | Glutamic-pyruvic transaminase |
| 52 | P01375 | 7124 | TNF | Tumor necrosis factor |
| 53 | P37231 | 5468 | PPARG | Peroxisome proliferator activated receptor gamma |
| 54 | O00206 | 7099 | TLR4 | Toll-like receptor 4 |
| 55 | P06213 | 3643 | INSR | Insulin receptor |
| 56 | P00505 | 2806 | GOT2 | Glutamic-oxaloacetic transaminase 2 |
| 57 | P01584 | 3553 | IL1B | Interleukin 1 beta |
| 58 | P05019 | 3479 | IGF1 | Insulin-like growth factor 1 |
| 59 | P41235 | 3172 | HNF4A | Hepatocyte nuclear factor 4 alpha |