Table 3.
Cluster of DSYM‐AS PPI network
| Cluster | Score | Nodes | Edges | Genes and Targets |
|---|---|---|---|---|
| 1 | 48.203 | 60 | 1422 | BCL2L1, MMP3, MMP2, MPO, IL17A, CCL5, IL10, IL18, ELANE, ITGAM, JUN, IL1B, TNFSF11, RELA, BDNF, HMOX1, SPP1, LOX, PTGS2, IL2, STAT1, MMP1, STAT3, FOS, PECAM1, CD34, HIF1A, MMP13, TIMP1, TGFB1, CD40, MAPK8, TNFRSF1A, CXCL8, CD40LG, SRC, CTNNB1, CASP3, PPARG, FGF2, CCL2, PLG, TP53, IL6, TNF, VCAM1, ADIPOQ, FOXP3, MMP9, ICAM1, TLR4, IFNG, EDN1, MAPK1, CSF1, LEP, TLR2, IL4, MMP7, KIT |
| 2 | 33.431 | 103 | 1705 | AR, SERPINC1, RETN, CAT, CASP1, F3, CX3CR1, AGTR1, LGALS3, AGT, CST3, CAV1, IGF1R, SMAD3, MAP2K1, PGR, BMP2, TNFRSF11B, EGFR, ADAM17, FBN1, CSF1R, PTPN11, TGFB3, IL1RN, CFD, PLAU, TGFB2, CDH5, F13A1, PF4, REN, MDM2, AKT1, SERPINF2, FGB, CD163, KDR, NOTCH1, SIRT1, GPT, FGF23, NOS2, CDKN2A, NFKB1, HMGB1, CXCL12, TEK, SERPIND1, APP, SELL, GRB2, CCR5, CX3CL1, PROC, RHOA, PGF, SDC2, CCR2, MAPK14, IL1A, IL1R1, FOXO3, CP, ANXA5, ANGPT1, CXCR2, FLT1, CXCR4, NR3C1, C4A, CDC42, JAK2, EGR1, APOE, MMP14, TNFSF10, IGFBP1, CYBB, CRP, PCSK9, SELE, ESR1, F8, APOA2, NOS3, HRAS, INS, ACE, HSP90AA1, NLRP3, VEGFA, SERPINE1, APOA5, SOCS1, SELP, LCK, EGF, IGF1, ALB, ELN, ENG, ALDOA |
| 3 | 10.897 | 79 | 425 | NPC2, MMP12, PIK3R1, KEAP1, HSPA1A, PDGFA, CTSG, CDK6, ACAN, IMPDH1, MTTP, ARSA, SYP, CHEK1, PRL, SPARC, CHUK, GRN, CYP19A1, BMP4, IKBKG, CTSK, DNMT1, C3, TGM2, NR1H4, NAMPT, CYBA, BPI, GC, HEXB, CLU, LYZ, HP, SELPLG, TGFBR1, ANG, NPC1L1, ITGB2, FABP5, EPHA2, H2AFX, RNASE3, APOH, VTN, ABCG8, LMNA, RBP4, ABCG5, SYK, FGA, RNASE2, CYP7A1, VCL, BCAR1, LPA, SERPINA1, APOC3, POSTN, RAC1, VCP, GM2A, CSK, LIPG, SREBF2, APCS, BACE1, FGG, FGFR1, PLCG1, PTX3, SCARB1, ZAP70, RAC2, ITGB3, ADRB2, POMC, ABCG1, HSP90AB1 |
| 4 | 9.855 | 84 | 409 | BGLAP, ABCB1, VWF, TTR, F2, APOC1, DCN, MET, HPRT1, ARG1, IRS1, JAK3, F5, GJA1, CTSB, ESR2, LCN2, RAF1, CD209, XIAP, HPGDS, AGTR2, CXCL16, APOA4, APLN, TXN, APOM, CCL11, AHSG, P2RY12, NFE2L2, NPY, PSAP, SOD2, IGFBP3, APOB, FGFR2, CETP, GFAP, KNG1, GNB3, PDGFB, LIPC, NQO1, NOX1, GGT1, LCAT, PTK2, ERBB4, IKBKB, PON1, SORL1, DUSP1, MSR1, NCF1, PIK3CA, JAG1, APOC2, VDR, PTPN1, PARP1, SOD1, SST, GSK3B, MMP8, MIF, THBD, CDK2, ITGAL, PLAT, CCNA2, CCL13, GSR, CASR, GPIHBP1, ALOX5, BTK, PLA2G7, ABL1, PLTP, MAPK10, AGER, AKT2, FGF1 |
| 5 | 6.704 | 55 | 181 | ITGAV, GSTP1, PRKCA, CRH, HSPA8, AURKA, SQSTM1, GSTA3, LRP1, GCK, MAPT, GSTM1, GSTA1, CYP2C9, KAT2B, MAPK12, APAF1, CRYZ, CASP7, PLK1, ITGA2B, SREBF1, DUSP6, GSTM3, GSTM2, GSTM5, CYP3A5, ROCK1, HTR2A, LTA4H, MAPK7, CDA, P2RY1, CYP2C19, UCP2, CYP2C8, VIP, PRKACA, SAA1, S100A9, GCLM, PPARA, FABP4, CTSS, ALPL, GHRL, AKR1B1, MTHFR, HK1, CYP1A1, GCLC, GSS, SOD3, PSEN1, UTS2 |
| 6 | 5.2 | 26 | 65 | TPI1, ADK, APRT, TXNRD2, PDE3B, PDE4D, GPI, EFEMP2, MFAP5, PNP, HAGH, CALM2, PRDX5, ACTC1, MTHFD1, UCK2, NME2, DCK, YARS, PSPH, PYGL, PDE4B, MYH11, SLC2A10, SORD, AHCY |
| 7 | 4.8 | 6 | 12 | EXO1, RECQL, PMS2, XRCC5, KIF11, FEN1 |
| 8 | 4.786 | 29 | 67 | NR1H3, LDLR, COG2, APOA1, ABCA1, CANT1, CD14, LPL, COL3A1, ATIC, F7, OLR1, SPG7, ITGA2, ANGPTL3, F11, HMGCR, F10, TREM1, QPCT, CHIT1, LTF, DPP4, F2R, PPBP, HSPD1, ITIH4, SDC4, BGN |
| 9 | 3.6 | 6 | 9 | GFPT1, GALE, GFPT2, CLPP, HTRA1, UAP1 |
| 10 | 3.2 | 16 | 24 | TGFBR2, RAB5A, GSTM4, G6PD, PDPK1, PIK3CB, ITK, INSR, CALM1, CTSD, ACTA2, GSTA4, GSTO1, SORT1, WAS, GLRX |
| 11 | 3.143 | 15 | 22 | DOT1L, HDAC8, ABCC1, RSAD2, TK1, DHFR, DHODH, GMPR2, SULT1E1, NT5M, TYMS, PPP1CC, FDPS, RNASEL, NR1I2 |
| 12 | 3 | 3 | 3 | COX5A, TFPI, PROCR |
| 13 | 3 | 15 | 21 | MB, TNNI3, MYLK, NPPB, AGPAT2, FCAR, FKBP1A, PRKG1, BMPR2, GBA, EDNRA, NPC1, CALM3, BST1, ACE2 |
| 14 | 3 | 7 | 9 | RPSA, TYMP, EPHX2, GART, WARS, CCT7, SHMT1 |
| 15 | 3 | 3 | 3 | DDX39B, SNRPA, RAN |
| 16 | 3 | 3 | 3 | RFK, PPCDC, ENPP1 |
| 17 | 3 | 3 | 3 | OAT, SRM, OTC |
| 18 | 2.8 | 11 | 14 | CYP4A11, MTR, GMPR, IMPDH2, UMPS, BHMT, MTRR, PLA2G10, CYP2J2, GLO1, PLA2G2A |