FIGURE 2.

Overview of the networks underlying the etiopathogenesis of Psoriasis and Psoriatic Arthritis discussed in this manuscript. In particular, the interactions among genetic (genes coding for tissue structural components, microbial recognition and inflammatory mediators), epigenetic (epigenetic changes and epigenetic modifiers) and non‐genetic (environment and microbiome) factors contribute to the onset and progression of both the diseases and may also account for peculiar blended phenotypes (such as the severe form characterized by nail, scalp and intergluteal skin involvement)