Table 4.
GO annotation of down‐regulated differentially expressed genes
| GO ID | Term | P‐value | Genes |
|---|---|---|---|
| Biological process | |||
| GO:0030198 | Extracellular matrix organization | 8.87 × 10−8 | COL10A1, COL16A1, COL1A2, COL5A1, COMP, CTGF, CTRB2, CTSK, CYR61, FBN1, GREM1, LUM, SULF1 |
| GO:0022617 | Extracellular matrix disassembly | 5.06 × 10−6 | COL10A1, COL16A1, COL1A2, COL5A1, CTRB2, CTSK, FBN1, MMP11 |
| GO:0044243 | Multicellular organismal catabolic process | 8.14 × 10−6 | CEL, COL10A1, COL16A1, COL1A2, COL5A1, CTSK, MMP11 |
| GO:0030574 | Collagen catabolic process | .000116 | COL10A1, COL16A1, COL1A2, COL5A1, CTSK, MMP11 |
| GO:0 030 199 | Collagen fibril organization | .000154 | COL1A2, COL5A1, GREM1, LUM, MMP11 |
| Cellular component | |||
| GO:0005576 | Extracellular region | 1.16 × 10−20 | ASPN, CDH11, CEL, CFTR, CHGB, COL10A1, COL16A1, COL1A2, COMP, CPB1, CPE, CTRB2, CTSK, CXCL14, CYR61, DKK3, DPEP1, FBN1, FCGBP, FRZB, FXYD2, GCG, GREM1, IGJ, INHBA, INS, ISLR, ITGBL1, LEFTY1, LUM, MMP11, OLFM4, PDGFD, PDGFRL, PNLIP, PPY, PRSS3, PTGDS, REG1A, REG1B, REG3A, SCG5, SCUBE2, SFRP4, SST, SULF1, THBS4, THY1 |
| GO:0005615 | Extracellular space | 1.58 × 10−15 | CEL, COL1A2, COMP, CTGF, CTRB2, CTSK, CXCL14, DKK3, DPEP1, FBN1, FRZB, GCG, GREM1, IGJ, INHBA, INS, LEFTY1, LUM, OLFM4, PPY, PRSS3, PTGDS, REG3A, SFRP4, SST, SULF1, THBS4 |
| GO:0005578 | Proteinaceous extracellular matrix | 7.48 × 10−7 | ASPN, COL10A1, COL16A1, COL1A2, COMP, CTGF, CYR61, FBN1, LUM, MMP11, THBS4 |
| GO:0031982 | Vesicle | 3.05 × 10−5 | CDH11, CEL, CFTR, CHGB, COL1A2, COL5A1, COMP, CPE, DPEP1, FBN1, FCGBP, FXYD2, GCG, IGJ, INS, ISLR, LUM, OLFM4, PDGFD, PRSS3, PTGDS, REG1A, REG1B, SCG5, STMN2, THBS4, THY1 |
| GO:0005788 | Endoplasmic reticulum lumen | 6.14 × 10−5 | COL10A1, COL16A1, COL1A2, COL5A1, GCG, INS, PDGFD |
| Molecular function | |||
| GO:0050839 | Cell adhesion molecule binding | 4.39 × 10−7 | COL16A1, COL5A1, CPE, CTGF, CYR61, FBN1, OLFM4, THBS4, THY1 |
| GO:0005102 | Receptor binding | 7.93 × 10−7 | CHGB, COL16A1, COL5A1, CPE, CTGF, CXCL14, CYR61, FBN1, GCG, GREM1, INHBA, INS, LEFTY1, PPY, REG1A, SST, THBS4, THY1 |
| GO:0005178 | Integrin binding | 2.44 × 10−6 | COL16A1, COL5A1, CTGF, CYR61, FBN1, THBS4, THY1 |
| GO:0032403 | Protein complex binding | 2.24 × 10−5 | COL16A1, COL5A1, COMP, CTGF, CTSK, CYR61, FBN1, IGJ, INS, LUM, THBS4, THY1 |
| GO:0005201 | Extracellular matrix structural constituent | 2.40 × 10−5 | COL1A2, COL5A1, COMP, FBN1, LUM, MFAP5 |