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. 2020 Nov 9;24(24):14549–14560. doi: 10.1111/jcmm.16083

Figure 5.

Figure 5

Farnesoid X receptor (FXR) transactivates the expression of SOCS3 by binding to the FXRE/IR9 in the SOCS3 promoter in colon cancer cells. A and B, The activities of the full SOCS3 promoter reporter construct and the truncated ones in Caco‐2 (A) and HT‐29 (B) cells after obeticholic acid (OCA) exposure using the dual‐luciferase assay. C, Schematic representation of a putative FXRE in the human SOCS3 promoter region (SOCS3/IR9). Enrichment level of FXR binding to the putative FXRE in the SOCS3 promoter region in Caco‐2 (D) and HT‐29 (E) cells determined by the qChIP assay. *P < .05