Figure 6.

Activation of the JAK2/STAT3 pathway rescues the inhibitory effect of Farnesoid X receptor (FXR) activation on the proliferation of colon cancer cells. A and B, The effect of colivelin and IL‐6 on the growth and viability of FXR‐activated Caco‐2 (A) and HT‐29 (B) cells detected by cell growth and CCK8 assays. C, FACS analysis of the cell cycle distribution of FXR‐activated Caco‐2 and HT‐29 cells after colivelin and IL‐6 exposure. D, Comparison of the cell cycle distribution. E, FACS analysis of PE/APC staining for apoptosis in FXR‐activated Caco‐2 and HT‐29 cells after colivelin and IL‐6 exposure. F, Quantification of apoptotic cells. *P < .05