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. 2020 Nov 1;24(23):13573–13588. doi: 10.1111/jcmm.16049

FIGURE 1.

FIGURE 1

Suppressive effects of berberine on the differentiation and inflammatory function of Th‐1 and Th‐17 cells. Berberine can inhibit differentiation of naive CD4+ T cells into Th‐1 cells through down‐regulating the expression of IL‐12, STAT1, STAT4 and T‐bet, and into Th‐17 cells through down‐regulating the expression of TGF‐β, IL‐6, IL‐23, RORγt and STAT3. Suppressive effects of berberine on the differentiation of Th‐1 and Th‐17 cells leads to reduced levels of pro‐inflammatory cytokines and decreased autoimmune inflammation