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. 2020 Nov 3;24(24):14467–14480. doi: 10.1111/jcmm.16069

FIGURE 5.

FIGURE 5

The effects of LINC00659 on cell cycle regulatory protein and PI3K‐AKT signals. A‐B, The effects of LINC00659 on cell cycle regulatory protein and PI3K‐AKT signals in SGC‐7901. The expression of the cell cycle regulatory protein, p21, Cyclin E, Cyclin D and CDK2 was significantly down‐regulated, and PI3K‐AKT signal was suppressed in the si‐LINC00659 group. Comparison with the Control group, *P < .05; comparison with si‐Negative group, #P < .05. C‐D, The effects of LINC00659 on cell cycle regulatory protein and PI3K‐AKT signals in BGC‐823. The expression of the cell cycle regulatory protein, p21, Cyclin E, Cyclin D and CDK2 was significantly down‐regulated, and PI3K‐AKT signal was suppressed in the si‐LINC00659 group. Comparison with the Control group, *P < .05; comparison with si‐Negative group, #P < .05