FIGURE 6.

The targeted regulation relationship between LINC00659 and SUZ12. A‐B, RNA‐IP assay confirmed that LINC00659 could bind with SUZ12 in gastric cancer cells, indicating the targeted relationship between the two. C, RNA pull‐down assay validated the targeted relationship between LINC00659 and SUZ12. The expression of SUZ12 was increased after pulling down the protein, confirming the binding relationship between the two. D‐F, The overexpression of LINC00659 caused increased expression level of both LINC00659 and SUZ12 in SGC‐7901 cells. G‐I, The overexpression of LINC00659 caused increased expression level of both LINC00659 and SUZ12 in BGC‐823cells. J‐K, Luciferase reporter gene assay showed the targeted relationship between LINC00659 and SUZ12