Figure 6.

miR‐19b/1281 antagomiR inhibits the functions of AG‐490 in mice. A, 1 mo after ~100 CFU of aerosolized Mtb infection, mice were given with AG‐490 (1 mg/kg) through i.p twice every 10 d through i.p for a total of 30 d, another 30 d later, each mouse was further given miR‐19b/1281 agomiR (5 nmol/100 μL); B, expression of miR‐19b/1281 in mouse lung tissues determined by Western blot analysis; C, secretion of pro‐inflammatory factors in mouse lung tissue homogenate determined by ELISA kits; D, Mtb content in lung tissues; E, lung fibrosis in mouse lung tissues determined by Masson's trichrome staining; F, apoptosis in lung tissues determined by TUNEL. Each spot in the images indicates one sample. N = 8 in each group. Three independent experiments were performed. Data were expressed as mean ± SD compared by one‐way ANOVA and Tukey's multiple comparison test. *P < .05, **P < .01