Figure 3.

USP15 function of was abolished by the AKT agonist IGF‐1. A, The apoptosis of oeUSP15‐transfected cells was suppressed in the presence of the AKT agonist IGF‐1. ***P < .001 vs oeNC; ###P < .001 vs oeUSP15. B, Western blotting was used to examine the protein expression levels of USP15, aggrecan and collagen in oeNC‐ or oeUSP15‐transfected cells treated with the AKT agonist IGF‐1 or untreated. ***P < .001 vs oeNC; ###P < .001 vs oeUSP15. C, The protein expression levels of Bcl2, Bax, p‐AKT and AKT were examined in different transfected cells as indicated. ***P < .001 vs oeNC; ###P < .001 vs oeUSP15