Table 5.
The Effect of Different Treatment Modalities on Induced Gastric Ulcer in Rats
| Treated Models | Abou Zeit-Har Score | Ulcer Area (mm2) | Ulcer Index |
|---|---|---|---|
| Saline (negative control) | 79.0±27.40 | 65.57±31.47 | 14.41±4.10 |
| Omeprazole (positive control) |
20.2±14.62* | 16.90±5.41* | 3.70±0.91* |
| Tadalafil aqueous suspension | 31.2±9.70* | 21.60±9.33* | 5.81±1.69* |
| Tadalafil-loaded limonene-based SNES ODTs | 0.2±0.45*■ | 0.053±0.12*■ | 0.01±0.03*■ |
| Limonene-based SNES ODTs | 1.6±2.07*■ | 0.24±0.25*■ | 0.06±0.06*■ |
Notes: n=5 (mean± sd); *Denotes significant difference from saline-treated group (negative control) (p < 0.05); ■Denotes significant difference from omeprazole treated group (positive control) (p<0.05).