TABLE 2.
Blood pressure data in 3 different dosing groups
| Dosing groups | Comparison between groups | |||||
|---|---|---|---|---|---|---|
|
1.0 mg/kg (n = 30) |
1.5 mg/kg (n = 23) |
2.0 mg/kg (n = 26) |
1.0 vs 1.5 | 1.0 vs 2.0 | 1.5 vs 2.0 | |
| Baseline MBP (mm Hg), mean (SD) | 40.5 (11.2) | 44.4 (9.7) | 42.4 (12.3) | P = .22 | P = .73 | P = .30 |
| Hypotension before propofol, n (%) | 4/29 (14) | 0/21 | 3/26 (12) | P = .13 | P = 1.0 | P = .24 |
| Hypotension at any time point after start of propofol, n (%) | 15/24 (63) | 11/21 (52) | 16/26 (62) | P = .56 | P = 1.0 | P = .57 |
| Treatment of hypotension with volume resuscitation, n (%) | 7/15 (47) | 4/11 (36) | 12/16 (75) | P = .70 | P = .15 | P = .06 |
| Lowest MBP (mm Hg) after start of propofol, mean (SD) | 27.8 (9.5) | 27.8 (6.9) | 27.1 (5.5) | P = .85 | P = .73 | P = .88 |
| Time after start of propofol (min) of lowest MBP, mean (SD) | 18.2 (12.5) | 22.6 (14.3) | 28.6 (18.2) | P = .24 | P = .04 | P = .25 |
| Maximum decrease in MBP as % from baseline, mean (SD) | −30 (16.5) | −36.4 (14.0) | −32.6 (18.7) | P = .07 | P = .15 | P = .73 |
Abbreviations: MBP, mean blood pressure; SD, standard deviation.