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. 2020 Jul 24;21(22):3197–3207. doi: 10.1002/cbic.202000381

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© 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Selected references with a high biosimilarity to DFO. A) Structures and B) morphological fingerprints of annotated reference compounds with high fingerprint similarity (BioSim >75 %) to 10 μM deferoxamine. The top line of the heatmap profile is set as a reference fingerprint (100 % BioSim) to which the following fingerprints are compared. The set of 579 parameters is divided in parameters related to the cell (1–229), cytoplasm (230–461) and nuclei (462–579). Values were normalized to the DMSO control. Blue: decreased parameter, red: increased parameter.