Table 5.
Predictors of Adverse Event in Patients With COVID-19 by Cox Proportional Hazard Model
| Variables | Univariate Cox regression | Model 1 Age + Lymphocytes% + Comorbidity |
Model 2 Age + Lymphocytes% + Comorbidity + LUS score |
Model 3 Age + Lymphocytes% + Comorbidity + LUS score > 12 |
||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| Age, years | 1.081 (1.057, 1.106) | < 0.001 | 1.040 (1.011, 1.070) | 0.007 | 1.032 (1.001, 1.063) | 0.041 | 1.028 (0.999, 1.059) | 0.06 |
| Male (yes vs. no) | 1.074 (0.558, 2.068) | 0.83 | ||||||
| BMI, Kg/m [2] | 0.828 (0.622, 1.103) | 0.197 | ||||||
| Lymphocytes% | 0.872 (0.836, 0.909) | < 0.001 | 0.892 (0.853, 0.932) | < 0.001 | 0.937 (0.892, 0.985) | 0.01 | 0.940 (0.897, 0.985) | 0.01 |
| CRP, mg/L | 1.007 (1.002, 1.012) | 0.01 | ||||||
| hs-TnI, ng/L | 1.000 (1.000, 1.001) | 0.004 | ||||||
| CK-MB, U/L | 1.004 (1.001, 1.008) | 0.022 | ||||||
| Comorbidity (yes vs. no) | 4.928 (2.417, 10.050) | < 0.001 | 0.994 (0.453, 2.182) | 0.987 | 0.545 (0.228, 1.299) | 0.171 | 0.695 (0.316, 1.528) | 0.366 |
| LUS score | 1.083 (1.065, 1.100) | < 0.001 | 1.049 (1.023, 1.076) | < 0.001 | ||||
| LUS score > 12 (yes vs. no) | 49.935 (15.296, 163.016) | < 0.001 | 10.760 (2.753, 42.049) | 0.001 | ||||
| AIC | 286 | 272 | 272 | |||||
| C-index | 0.866 | 0.903 | 0.902 | |||||
P < 0.05 was considered statistically significant. AIC, Akaike information criterion; C-index, concordance index; CK-MB, creatine kinase muscle-brain; CRP, C-reactive protein; hs-TnI, hypersensitive troponin I; CI, confidence interval; HR, hazard ratio