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A) Microglia constantly surveils the neural environment, and a) its motile processes respond to synaptic activity through P2Y12 receptor by sensing ATP released during neurotransmission. B) Microglia, through its C3 receptor, identifies synapses to be pruned through complement molecules C1q and C3. C1q expression on neurites may be regulated through astrocyte-secreted TGF-β.
