. 2020 Aug 31;25(4):356–365. doi: 10.1111/jns.12408

TABLE 4.

Secondary endpoints‐change from baseline to EOS visit in neurological scores and grip strength‐FAS (overall, N = 42)

Parameters	Number of patients	Mean ± SD	Min‐max	Hodges‐Lehmann median (95% CI) ^a	Wilcoxon signed‐rank test ^b
Change in adjusted INCAT disability score Range: 0 (no disability) to 9 (maximal disability)	42	−1.2 ± 1.28	−5‐1	−1.0 [−1.5; −1.0]	P < .0001
Change in R‐ODS score Range: 0 (most severe limitations) to 48 (no limitations)	42	4.0 ± 8.5	−12‐32	3.5 [1.0; 6.0]	P = .0036
Change in MRC sum score Range: 0 (total paralysis) to 60 (normal muscle strength)	41	3.48 ± 5.8	−11‐18	3.0 [2.0; 5.0]	P = .0001
Change in Rasch‐modified MRC sum score Range: 0 (total paralysis) to 36 (normal muscle strength)	41	2.8 ± 3.7	−5‐11	2.5 [1.5; 3.5]	P < .0001
Change in grip strength in dominant hand Normalized values (%) ^c	41	12.0 ± 26.9	−17.8‐109.5	6.2 [1.1; 13.1]	P = .0076
Change in grip strength in non‐dominant hand Normalized values (%) ^c	41	12.8 ± 29.1	−19.6‐119.1	5.9 [0.2; 14.0]	P = .0147

Abbreviations: CI, confidence interval; EOS, end of study; FAS, full analysis set; INCAT, inflammatory neuropathy cause and treatment; MRC, medical research council; R‐ODS, Rasch‐built‐overall disability scale.

^{^a}

Hodges‐Lehmann median‐unbiased estimate of the population median and associated 95% confidence interval.

^{^b}

Wilcoxon signed‐rank test using a two‐sided significance level of 5% (difference between the visit and baseline scores did not follow a symmetric distribution around zero).

^{^c}

Grip strength is reported as the absolute values (in kPa) expressed in percentage of the median value in a healthy population of the same age and gender. ¹⁰