. 2020 Sep 3;21(10):617–624. doi: 10.1111/hiv.12878

Table 3.

DAA HCV treatment options (except for persons pretreated with protease or NS5A inhibitors) to be used if preferred option is not avaible

HCV GT	Treatment regimen	Treatment duration and RBV usage
HCV GT	Treatment regimen	Noncirrhotic	Compensated cirrhotic	Decompensated cirrhotic CTP class B/C
1 and 4	OBV/PTV/r + DSV	8 ^a –12 weeks in GT 1b	12 weeks in GT 1b	Not recommended
	OBV/PTV/r + DSV + RBV	12 weeks in GT 1a	24 weeks in GT 1a	Not recommended
	OBV/PTV/r + RBV	12 weeks in GT 4		Not recommended
	SOF + DCV ± RBV	12 weeks ± RBV ^b	12 weeks with RBV ^c
	SOF/VEL/VOX	8 weeks ^d	12 weeks	Not recommended
2	SOF + DCV	12 weeks		12 weeks with RBV
2	SOF/VEL/VOX	8 weeks ^d	12 weeks	Not recommended
3	SOF + DCV ± RBV	12 weeks ± RBV ^e or 24 weeks without RBV	24 weeks with RBV
3	SOF/VEL/VOX	8 weeks ^d	12 weeks	Not recommended
5 and 6	SOF + DCV ± RBV	12 weeks ± RBV or 24 weeks without RBV ^f	12 weeks with RBV ^c
5 and 6	SOF/VEL/VOX	8 weeks ^d	12 weeks	Not recommended

CTP, child‐Turcotte‐Pugh; DAA, direct‐acting antiviral; DCV, daclatasvir; DSV, dasabuvir; EBR, elbasvir; GLE, glecaprevir; GT, genotype; GZR, grazoprevir; LDV, ledipasvir; NS5A, Nonstructural protein 5A; OBV, ombitasvir; PIB, pibrentasvir; PTV/r, paritaprevir/RTV; RAS, resistance‐associated substitution; RBV, ribavirin; SOF, sofosbuvir; VEL, velpatasvir; VOX, voxilaprevir.

^{^a}

8 weeks of treatment without RBV only in PLWH without cirrhosis.

^{^b}

Addition of RBV in GT1a treatment‐experienced PLWH, but not in PLWH without NS5A RASs, if RAS testing is available.

^cIn PLWH intolerant to RBV, treatment may be prolonged to 24 weeks. : RBV can be omitted in treatment‐naïve or ‐experienced PLWH with compensated cirrhosis without baseline NS5A RAS.

^{^d}

Extension of treatment to 12 weeks in DAA treatment‐experienced PLWH.

^{^e}

Addition of RBV only in treatment‐experienced persons with baseline NS5A RASs, if RAS testing available; if these PLWH are intolerant to RBV, treatment may be prolonged to 24 weeks without RBV.

^{^f}

In treatment‐experienced (exposure to IFN/RBV/SOF) PLWH, treat with RBV for 12 weeks or prolong treatment to 24 weeks without RBV.