FIGURE 1.

Cardiovascular outcomes by baseline body mass index category in A, LEADER and B, SUSTAIN 6. Primary and expanded MACE analyses adjusted for sex, smoking status, antihyperglycaemic treatments, prior cardiovascular (CV) events, geographic region, age, diabetes duration, estimated glomerular filtration rate. Smoking status was not adjusted for in the SUSTAIN 6 analysis for CV death because of low event numbers. ^†Primary major adverse cardiovascular events (MACE): composite of CV death, non‐fatal myocardial infarction (MI) and non‐fatal stroke. ^‡Expanded MACE: components of primary MACE plus revascularization (coronary only in LEADER; coronary or peripheral in SUSTAIN 6) or hospitalization for unstable angina pectoris or heart failure. BMI, body mass index (in kg/m²); CI, confidence interval; HR, hazard ratio