Table 4.
Initial and maximum dosages of systemic therapy
| Ciclosporin | Azathioprine | Methotrexate | Mycophenolic acid | Oral corticosteroids | |||||
|---|---|---|---|---|---|---|---|---|---|
| n = 201 | n = 135 | n = 199 | n = 85 | n = 184 | |||||
| mg kg−1 per day | mg kg−1 per day | mg per week | g per day | mg kg−1 per day | |||||
| Initial dose | |||||||||
| Dose | n (%) | Dose | n (%) | Dose | n (%) | Dose | n (%) | Dose | n (%) |
| < 2·5 | 22 (10·9) | < 1 | 20 (14·8) | < 5 | 6 (3·0) | < 1 | 11 (13) | < 0·5 | 75 (40·8) |
| 2·5–3·5 | 110 (54·7) | 1–2 | 98 (72·6) | 5–10 | 60 (30·2) | 1–1·5 | 40 (47) | 0·5–1·0 | 107 (58·2) |
| 3·6–4·5 | 37 (18·4) | 2·1–3 | 17 (12·6) | 11–15 | 109 (54·8) | 1·6–2 | 32 (38) | > 1·0 | 2 (1·1) |
| 4·6–5·0 | 32 (15·9) | > 3 | 0 (0·0) | 16–20 | 22 (11·1) | > 2 | 2 (2) | ||
| > 5·0 | 0 (0·0) | 21–25 | 2 (1·0) | ||||||
| > 25 | 0 (0·0) | ||||||||
| Maximum dose | |||||||||
| Dose | n (%) | Dose | n (%) | Dose | n (%) | Dose | n (%) | Dose | n (%) |
| < 2·5 | 2 (1·0) | < 1 | 2 (1·5) | < 5 | 1 (0·5) | < 1 | 2 (2) | < 0·5 | 24 (13·0) |
| 2·5–3·5 | 32 (15·9) | 1–2 | 53 (39·3) | 5–10 | 8 (4·0) | 1–1·5 | 12 (14) | 0·5–1·0 | 146 (79·3) |
| 3·6–4·5 | 42 (20·9) | 2·1–3 | 76 (56·3) | 11–15 | 33 (16·6) | 1·6–2 | 51 (60) | > 1·0 | 14 (7·6) |
| 4·6–5·0 | 120 (59·7) | > 3 | 4 (3·0) | 16–20 | 69 (34·7) | > 2 | 20 (24) | ||
| > 5·0 | 5 (2·5) | 21–25 | 87 (43·7) | ||||||
| > 25 | 1 (0·5) | ||||||||