TABLE 1.
Demographics and clinical baseline characteristics
| Parameter | PD01A | PD03A | Placebo | Total | |
|---|---|---|---|---|---|
| (n = 12) | (n = 12) | (n = 6) | (n = 30) | ||
| Age (years) | Median (range) | 62 | 60 | 66 | 61 |
| (42–74) | (47–71) | (48–70) | (42–74) | ||
| Body weight (kg) | Median (range) | 69.5 | 76.5 | 73.0 | 73.0 |
| (45–97) | (56–102) | (57–94) | (45–102) | ||
| Sex, n | Female | 6 | 4 | 1 | 11 |
| Male | 6 | 8 | 5 | 19 | |
| Time since symptom onset (years) | Mean | 2.93 | 2.50 | 2.88 | 2.75 |
| Time since MSA diagnosis (years) | Mean | 0.68 | 0.79 | 0.82 | 0.75 |
| MSA‐P/MSA‐C | Number | 7/5 | 6/6 | 1/5 | 14/16 |
| UMSARS I score | Median (range) | 16.0 | 16.5 | 15.5 | — |
| (4–25) | (8–21) | (10–27) | |||
| UMSARS II score | Median (range) | 14.5 | 18.5 | 14.5 | — |
| (7–32) | (11–27) | (12–29) | |||
| UMSARS III: systolic blood pressure in supine position (mm Hg) | Median (range) | 128 | 142 | 135 | — |
| (103–223) | (104–170) | (116–203) | |||
| UMSARS III: diastolic blood pressure in supine position (mm Hg) | Median (range) | 79 | 83 | 85 | — |
| (63–125) | (67–100) | (70–96) | |||
| Maximal drop in systolic blood pressure (mm Hg) | Mean | 30 | 28 | 31 | — |
| Maximal drop in diastolic blood pressure (mm Hg) | Mean | 13 | 13 | 14 | — |
| UMSARS III: orthostatic symptoms | No/yes | 8/4 | 7/5 | 4/2 | — |
| UMSARS IV | Median (range) | 2 | 2 | 2 | — |
| (1–4) | (1–2) | (1–3) | |||
| GDS | Median (range) | 4.0 | 5.5 | 7.5 | — |
| (0–9) | (0–11) | (2–10) | |||
| COMPASS 31 score | Median (range) | 41.0 | 37.1 | 53.1 | — |
| (3.2–56.6) | (11.1–57.1) | (1.9–59.8) |
UMSARS, Unified Multiple System Atrophy Rating Scale I–IV; GDS, Geriatric Depression Scale; COMPASS 31, Composite Autonomic Symptom Score; data from ITT population.