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Summary of Simcyp‐Simulated and Observed Molibresib PK Parameters
| AUC0‐t (ng·h/mL), CV% | Cmax (ng/mL), CV% | |||
|---|---|---|---|---|
| Dose | Predicted | Observed a | Predicted | Observed a |
| 60 mg | 4271 (56) | 4255 (39.2) | 628.7 (46) | 889.5 (24.5) |
| 100 mg | 7119 (56) | 6958 (43.5) | 1048 (46) | 1081 (38.8) |
Cmax, maximum concentration; AUC0‐t, area under the curve from 0 to time t, t being 24 hours.
Piha‐Paul et al. 6
