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. 2020 Aug 20;61(1):125–137. doi: 10.1002/jcph.1711

Table 6.

Simcyp Prediction for Rifampicin Effect on PK Parameters of Molibresib and Its Two Active Metabolites (GSK3529246)

Molibresib GSK3529246
Parameter Predicted Ratio (5th and 95th Percentiles) Predicted Ratio (5th and 95th Percentiles)
Cmax 0.51 (0.48, 0.54) 1.13 (1.12, 1.14)
AUC 0.21 (0.20, 0.23) 1.98 (1.91, 2.06)

Cmax, maximum concentration; AUC, area under the curve from 0 to infinity.

The predicted ratios are presented as geometric mean and 5th and 95th percentiles for 100 simulated subjects.