Table 4.
Parameter Estimates of Final Cox Models for Selected TEAEs
| Parameter | Estimate | SE | HR | 95%CI of HR | P |
|---|---|---|---|---|---|
| ≥ Grade 3 TEAEs | |||||
| Asian (vs non‐Asian) | 0.4736 | 0.2338 | 1.606 | 1.016‐2.539 | .0279 |
| AUCTEAE (μg·day/mL) × 50 | −0.2195 | 0.1169 | 0.803 | 0.639‐1.010 | .0538 |
| ≥ Grade 1 bone pain | |||||
| Asian (vs non‐Asian) | −1.3755 | 0.3507 | 0.253 | 0.127‐0.503 | .0002 |
| Splenectomy, yes | −0.6107 | 0.2366 | 0.543 | 0.342‐0.863 | .0216 |
| AUCTEAE (μg·day/mL) × 50 | −0.2718 | 0.1158 | 0.762 | 0.607‐0.956 | .0153 |
AUCTEAE, area under the concentration‐time curve at steady state during the dosing interval when the event occurred; CI, confidence interval; HR, hazard ratio; P, tail probability of the chi‐squared distribution (likelihood ratio test); SE, standard error; TEAE, treatment‐emergent adverse event.