Table 1.

Eligibility Criteria Based on the PICOS (Population, Intervention, Control, Outcomes) Tool

	Inclusion Criteria	Exclusion Criteria
Population	Patients who are candidates for anterior cruciate ligament reconstruction (ACLR)	All other indications
Intervention	Allograft cruciate ligament reconstruction	Other forms of therapy (e.g., using other graft choices)/conservative management
Control	Other techniques of cruciate ligament reconstruction (autograft, synthetic graft, etc.) Conservative management	No restriction
Outcomes
Effectiveness	Crucial: Patient-reported function, activity level and symptoms measured using a validated instrument (e.g., Lysholm score, Tegner score, IKDC scores) Important: Clinical knee stability measured using a validated instrument (e.g., KT-1000/2000 arthrometer, the Lachman test or pivot shift test), health-related quality of life measured using a validated instrument, patient satisfaction measured using a validated instrument	All other outcomes
Safety	Crucial: Graft failure, re-ruptures, re-operations and revisions, complications Important: Procedure-related mortality	All other outcomes
Study design	Randomized controlled trials with mean follow up of at least 5 years and more than 50 patients.	Randomized controlled trials with a mean follow-up of less than 5 years and less or equal to 50 enrolled patients. Not-randomized trials, observational studies. Studies published as an abstract only.

IKDC, International Knee Documentation Committee.