Table 3.

Diagnostic performance of quantitative sensory testing, nerve conduction and CCM in the diagnosis of diabetic peripheral neuropathy

Neuropathy measure	AUC	P value	Sensitivity (%)	Specificity (%)	Youden’s cut-off point
VPT	0.79	<0.0001	55	90	17.37
WPT	0.67	<0.001	50	76	44.2
CPT	0.64	<0.002	80	47	27.3
SNCV	0.70	<0.01	76	54	45.9
CNFD	0.71	<0.0001	58	83	23.95
CNBD	0.70	<0.0001	69	65	58.54
CNFL	0.68	<0.0001	64	67	21.6
IWL	0.72	<0.0001	70	65	24.4
ANFL	0.72	<0.0001	71	66	23.4

ANFL, average nerve fiber length; AUC, area under the curve; CCM, corneal confocal microscopy; CNBD, corneal nerve branch density; CNFD, corneal nerve fiber density; CNFL, corneal nerve fiber length; CPT, cold perception threshold; IWL, inferior whorl length; SNCV, sural nerve conduction velocity; VPT, vibration perception threshold; WPT, warm perception threshold.