Table 3.

HRs of each antibiotic by anatomic sites and temporal order of drug exposure

	Temporal exposure	Any tendon rupture	Achilles tendon rupture	Complete rupture of rotator cuff	Other tendon ruptures	Death (competing risk)
		HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)
AMX versus NO AMX	≤30 days	0.86 (0.80 to 0.92) ↡	0.88 (0.59 to 1.33)	0.88 (0.82 to 0.95) ↓	0.79 (0.67 to 0.93) ↓	0.66 (0.61 to 0.71) ↡
	31–60 days	0.94 (0.87 to 1.01)	0.80 (0.49 to 1.31)	0.91 (0.84 to 0.99) ↓	1.08 (0.93 to 1.27)	0.69 (0.63 to 0.75) ↡
	≥61 days	1.00 (0.98 to 1.02)	0.99 (0.86 to 1.13)	1.01 (0.99 to 1.04)	0.97 (0.92 to 1.01)	0.77 (0.75 to 0.78) ↡
AMC versus NO AMC	≤30 days	0.93 (0.85 to 1.02)	1.25 (0.79 to 1.97)	0.87 (0.79 to 0.97) ↓	1.17 (0.98 to 1.41)	1.37 (1.30 to 1.45) ↟
	31–60 days	0.95 (0.85 to 1.05)	1.37 (0.82 to 2.29)	0.95 (0.84 to 1.06)	0.81 (0.63 to 1.04)	1.26 (1.17 to 1.35) ↟
	≥61 days	1.07 (1.04 to 1.09) ↟	0.95 (0.81 to 1.12)	1.07 (1.04 to 1.10) ↟	1.02 (0.96 to 1.08)	0.86 (0.84 to 0.88) ↡
AZM versus NO AZM	≤30 days	0.99 (0.93 to 1.06)	1.15 (0.82 to 1.63)	1.00 (0.93 to 1.08)	0.87 (0.75 to 1.01)	0.80 (0.75 to 0.84) ↡
	31–60 days	0.90 (0.84 to 0.98) ↓	0.99 (0.65 to 1.49)	0.91 (0.84 to 0.99) ↓	0.95 (0.81 to 1.11)	0.77 (0.73 to 0.82) ↡
	≥61 days	1.07 (1.05 to 1.09) ↟	1.02 (0.91 to 1.15)	1.09 (1.07 to 1.12) ↟	0.99 (0.95 to 1.04)	0.71 (0.70 to 0.72) ↡
LEX versus NO LEX	≤30 days	1.31 (1.22 to 1.41) ↟	1.93 (1.35 to 2.75) ↟	1.19 (1.09 to 1.29) ↟	1.79 (1.56 to 2.06) ↟	1.04 (0.98 to 1.10)
	31–60 days	1.05 (0.95 to 1.15)	1.14 (0.66 to 1.96)	1.06 (0.96 to 1.18)	1.02 (0.82 to 1.26)	1.01 (0.94 to 1.08)
	≥61 days	1.08 (1.05 to 1.11) ↟	1.00 (0.85 to 1.16)	1.07 (1.05 to 1.10) ↟	1.15 (1.09 to 1.21) ↟	0.86 (0.84 to 0.88) ↡
LVX versus NO LVX	≤30 days	1.14 (1.05 to 1.25) ↑	2.20 (1.50 to 3.24) ↟	1.16 (1.06 to 1.28) ↑	0.96 (0.78 to 1.19)	2.19 (2.11 to 2.28) ↟
	31–60 days	1.09 (0.98 to 1.21)	1.91 (1.17 to 3.10) ↑	1.09 (0.97 to 1.22)	1.14 (0.90 to 1.43)	1.80 (1.71 to 1.89) ↟
	≥61 days	1.02 (1.00 to 1.05)	1.22 (1.03 to 1.43) ↑	1.03 (1.00 to 1.07) ↑	0.97 (0.91 to 1.03)	0.99 (0.97 to 1.01)
CIP versus NO CIP	≤30 days	0.96 (0.89 to 1.03)	1.06 (0.70 to 1.60)	0.96 (0.88 to 1.04)	0.84 (0.71 to 1.00) ↓	1.46 (1.40 to 1.53) ↟
	31–60 days	0.92 (0.85 to 1.01)	1.02 (0.63 to 1.67)	0.91 (0.82 to 1.00) ↓	0.95 (0.78 to 1.14)	1.31 (1.24 to 1.38) ↟
	≥61 days	0.96 (0.94 to 0.98) ↡	1.16 (1.02 to 1.32) ↑	0.96 (0.94 to 0.99) ↓	0.92 (0.88 to 0.97) ↓	0.86 (0.84 to 0.88) ↡
MXF versus NO MXF	≤30 days	0.59 (0.37 to 0.93)	0.97 (0.15 to 6.24)	0.52 (0.30 to 0.91) ↓	0.76 (0.33 to 1.77)	2.05 (1.78 to 2.35) ↟
	31–60 days	0.71 (0.43 to 1.15)	0.00 (0.00 to 0.00)	0.63 (0.35 to 1.13)	0.93 (0.39 to 2.25)	1.43 (1.18 to 1.72) ↟
	≥61 days	0.99 (0.93 to 1.06)	1.02 (0.69 to 1.51)	0.99 (0.92 to 1.06)	1.10 (0.95 to 1.27)	0.89 (0.86 to 0.93) ↡
FLQ versus AMX	≤30 days	1.00 (0.84 to 1.19)	1.49 (0.69 to 3.19)	0.94 (0.77 to 1.16)	1.08 (0.77 to 1.50)	2.86 (2.61 to 3.13) ↟
	31–60 days	0.95 (0.79 to 1.15)	0.07 (0.04 to 0.12) ↡	0.94 (0.75 to 1.17)	0.92 (0.65 to 1.31)	2.18 (1.96 to 2.44) ↟
	≥61 days	0.99 (0.96 to 1.02)	1.14 (0.94 to 1.40)	0.98 (0.95 to 1.02)	1.03 (0.96 to 1.11)	1.19 (1.16 to 1.22) ↟
FLQ versus AZM	≤30 days	0.87 (0.73 to 1.03)	1.14 (0.54 to 2.39)	0.83 (0.68 to 1.02)	0.98 (0.70 to 1.37)	2.35 (2.18 to 2.53) ↟
	31–60 days	0.99 (0.82 to 1.19)	0.06 (0.04 to 0.09) ↡	0.93 (0.75 to 1.16)	1.06 (0.75 to 1.49)	1.94 (1.77 to 2.13) ↟
	≥61 days	0.93 (0.90 to 0.96) ↡	1.10 (0.91 to 1.34)	0.91 (0.88 to 0.94) ↡	1.00 (0.93 to 1.08)	1.29 (1.25 to 1.32) ↟
FLQ versus LEX	≤30 days	0.66 (0.55 to 0.78) ↡	0.68 (0.32 to 1.42)	0.70 (0.57 to 0.87) ↓	0.47 (0.34 to 0.66) ↡	1.80 (1.67 to 1.95) ↟
	31–60 days	0.85 (0.70 to 1.04)	0.05 (0.03 to 0.09) ↡	0.80 (0.64 to 1.01)	0.99 (0.68 to 1.44)	1.48 (1.34 to 1.64) ↟
	≥61 days	0.92 (0.89 to 0.95) ↡	1.13 (0.92 to 1.40)	0.92 (0.89 to 0.96) ↡	0.86 (0.80 to 0.93) ↡	1.06 (1.03 to 1.09) ↟
FLQ versus AMC	≤30 days	0.93 (0.77 to 1.11)	1.05 (0.48 to 2.32)	0.96 (0.77 to 1.19)	0.72 (0.51 to 1.02)	1.37 (1.27 to 1.48) ↟
	31–60 days	0.94 (0.77 to 1.15)	0.04 (0.02 to 0.07) ↡	0.90 (0.72 to 1.14)	1.24 (0.83 to 1.86)	1.19 (1.08 to 1.31) ↟
	≥61 days	0.93 (0.90 to 0.97) ↡	1.19 (0.95 to 1.49)	0.93 (0.89 to 0.96) ↡	0.98 (0.90 to 1.06)	1.06 (1.03 to 1.09) ↟

↟=very significantlyincreased with p <0.001, ↑=significantly increased with 0.001≤ p <0.05.

↡=very significantly decreased with p <0.001, ↓=significantly decreased with 0.001≤ p <0.05.

AMC, amoxicillin clavulanate; AMX, amoxicillin; AZT, azithromycin; CIP, ciprofloxacin; FLQ, fluoroquinolone; LEX, cephalexin; LVX, levofloxacin; MXF, moxifloxacin.