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. 2020 Dec 18;218(1):e20190218. doi: 10.1084/jem.20190218

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© 2020 Abdul Pari et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 3. — Metastatic niche–imposed molecular checkpoints. Seeded tumor cells closely interact with different stromal cells within the metastatic niche. MICs escape dormancy by inducing the angiogenic switch (activation of otherwise quiescent ECs to induce sprouting angiogenesis), remodel the ECM, and orchestrate an immunosuppressive environment to collectively favor the colonization process. The figure was generated with BioRender.com.