Table 2.
Incidence rate and hazards ratios for composite CVD outcomes among SB patient population.
| Number of subjects | CVD events | Persons_years of follow-up | Incidence rate (95% CI) of CVD | Unadjusted hazards ratio for CVD | Adjusted HR for age and sexb | |
|---|---|---|---|---|---|---|
| All subjects in SB register | 2988 | 1327 | 52,090 | 25.47 (24.14–26.88) | ||
| Sex | ||||||
| Male | 1418 | 669 | 24,630 | 27.17 (25.18–29.30) | 1.00 | 1.00 |
| Female | 1570 | 658 | 27,470 | 23.96 (22.19–25.86) | 0.89 (0.80–0.99) | 0.65 (0.58–0.73) |
| Age at registration (years) | ||||||
| <30 | 614 | 89 | 14,100 | 6.31 (5.12–7.77) | 1.00 | 1.00 |
| 30 - <40 | 568 | 204 | 10,950 | 18.64 (16.25–21.38) | 3.38 (2.63–4.34) | 3.32 (2.59–4.26) |
| 40 - <50 | 620 | 305 | 10,770 | 28.31 (25.30–31.67) | 5.50 (4.34–6.98) | 5.44 (4.29–6.90) |
| 50 - <60 | 674 | 379 | 10,440 | 36.29 (32.81–40.13) | 8.09 (6.40–10.23) | 8.54 (6.75–10.80) |
| 60 - <70 | 425 | 293 | 5090 | 57.51 (51.29–64.49) | 16.21 (12.68–20.74) | 17.88 (13.96–22.91) |
| >70 | 87 | 57 | 740 | 77.35 (59.67–100.28) | 26.16 (18.58–36.84) | 29.90 (21.18–42.20) |
| FH diagnosis type | ||||||
| Definite FH | 1584 | 726 | 28,150 | 25.79 (23.99–27.74) | 1.00 | 1.00 |
| Possible FH | 1404 | 601 | 23,950 | 25.10 (23.17–27.18) | 1.00 (0.90–1.12) | 0.84 (0.75–0.93) |
| Past history of CVD | ||||||
| No past history of CVD | 2290 | 720 | 43,900 | 16.40 (15.25–17.64) | 1.00 | 1.00 |
| Past history of CVD | 698 | 607 | 8190 | 74.10 (68.44–80.24) | 5.90 (5.27–6.60) | 3.45 (3.06–3.89) |
Previous CVD includes previous CHD, MI, coronary revascularisation interventions (coronary angioplasty or CABG), stroke, TIA, intermittent claudication.
b
HR for CVD in males and females was adjusted for age only, and HR for CVD in different age categories was adjusted for sex only.