Table 3.
Observed and expected number of CVD events in men and women with FH in the Simon Broome register.
| Person-years of follow-up | Observed CVD events | Incidence rates/1000 person years (95% CI) | Expected CVD eventsa | Standardised morbidity ratio (95% CI) | |
|---|---|---|---|---|---|
| Males | |||||
| <30 years | 6942 | 56 | 8.07 (6.21–10.48) | 3.47 | 16.13 (12.42–20.96) |
| 30 to <50 years | 12,174 | 331 | 27.19 (24.41–30.28) | 32.99 | 10.03 (9.01–11.17) |
| 50 years | 5510 | 282 | 51.18 (45.54–57.51) | 61.49 | 4.59 (4.08–5.15) |
| Total (men) | 24,627 | 669 | 27.17 (25.18–29.30) | 97.96 | 6.83 (6.33–7.37) |
| Females | |||||
| <30 years | 7157 | 33 | 4.61 (3.28–6.49) | 2.15 | 15.37 (10.93–21.62) |
| 30 to <50 years | 9546 | 178 | 18.65 (16.10–21.60) | 11.84 | 15.04 (12.98–17.42) |
| >50 years | 10,765 | 447 | 41.52 (37.85–45.56) | 73.20 | 6.11 (5.57–6.70) |
| Total (women) | 27,468 | 658 | 23.96 (22.19–25.86) | 87.18 | 7.55 (6.99–8.15) |
| Overall | 52,094 | 1327 | 25.47 (24.14–26.88) | 185.14 | 7.17 (6.79–7.56) |
a
Expected CVD events derived by applying age and sex-specific CVD incidence rates in the UK general practice population of non-FH subjects [2], to the number of person-years of follow-up.