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. 2020 Dec 10;183(6):1586–1599.e10. doi: 10.1016/j.cell.2020.09.061

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© 2020 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Targeted Stimulation of Reward-Zone Place Cells Drives Reward-Zone-Related Behavior

(A) Place cell population average ΔF/F across virtual space from an example Reward-PC stimulation session; top is the baseline epoch and bottom is the stimulation epoch, and neurons in both plots are ordered and normalized by their peak during the baseline epoch.

(B) Raster plot of licking across space from the baseline and stimulation epochs of one example reward place cell stimulation session. Red circles denote licks that caused a trial to end in failure by crossing the threshold for the number of licks allowed outside of the reward zone. Only trials where the animal reached the stimulation point are shown, and trial numbers have been matched between epochs by taking trials from the end of the baseline epoch.

(C) Average lick-rate distribution across space for baseline and Reward-PC stimulation epochs across all Reward-PC stimulation sessions. Note the increased lick rate during stimulation.

(D) Change in lick rate from baseline across space during Reward-PC and Start-PC stimulation epochs, averaged within and then across animals (n = 7 mice).

(E) Summary of the within mouse change in licking caused by Reward-PC and Start-PC stimulation.

(F) Change in lick rate from baseline during non-place cell stimulation sessions (n = 6 mice) and no-stimulation control sessions (n = 9 mice).

(G) Correlation between number of responsive target population neurons and change in lick rate from baseline for Reward-PC, Start-PC, and Non-PC sessions.

(H) The total number of stimulated neurons across all sessions does not correlate to the change in licking.

(I) Place cell stimulation efficacy correlates with the observed change in licking (see STAR Methods).

(J) Change in reward-zone lick rate during stimulation epoch or no-stimulation equivalent.

(K) Summary of trial outcome changes during stimulation experiments relative to baseline data.

(L) Change in reward-zone lick rate separately for running overshoot and other trials during Start-PC stimulation sessions where there was an increase in running overshoots (n = 6 sessions).

^∗p < 0.05, ^∗∗p < 0.01; all error bars show SEM.